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PI4KB phosphatidylinositol 4-kinase beta [ Homo sapiens (human) ]

Gene ID: 5298, updated on 7-Oct-2018

Summary

Official Symbol
PI4KBprovided by HGNC
Official Full Name
phosphatidylinositol 4-kinase betaprovided by HGNC
Primary source
HGNC:HGNC:8984
See related
Ensembl:ENSG00000143393 MIM:602758; Vega:OTTHUMG00000012348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIK; PI4K92; PIK4CB; PI4KBETA; PI4K-BETA; PI4KIIIBETA
Expression
Ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.6) and 25 other tissues See more
Orthologs

Genomic context

See PI4KB in Genome Data Viewer
Location:
1q21.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (151291797..151327715, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151264273..151300191, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 4 Neighboring gene ZNF687 antisense RNA 1 Neighboring gene zinc finger protein 687 Neighboring gene RNA, 7SL, cytoplasmic 444, pseudogene Neighboring gene regulatory factor X5 Neighboring gene glioblastoma multiforme-associated transcript 2 Neighboring gene selenium binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30129, DKFZp686O1820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-phosphatidylinositol 4-kinase activity TAS
Traceable Author Statement
more info
 
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome TAS
Traceable Author Statement
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol 4-kinase beta
Names
PtdIns 4-kinase beta
phosphatidylinositol 4-kinase, catalytic, beta
phosphatidylinositol 4-kinase, wortmannin-sensitive
type III phosphatidylinositol 4-kinase beta
NP_001185702.1
NP_001185703.1
NP_001185704.1
NP_001317650.1
NP_002642.1
XP_005245321.1
XP_011507936.1
XP_011507937.1
XP_011507938.1
XP_011507939.1
XP_011507940.1
XP_016856975.1
XP_016856976.1
XP_016856977.1
XP_016856979.1
XP_016856980.1
XP_016856981.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198773.2NP_001185702.1  phosphatidylinositol 4-kinase beta isoform 2

    See identical proteins and their annotated locations for NP_001185702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, resulting in a downstream AUG start codon, and also lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AB005910, AK311292, AL391069, BC040300, U81802
    Consensus CDS
    CCDS55638.1
    UniProtKB/Swiss-Prot
    Q9UBF8
    Related
    ENSP00000357866.1, OTTHUMP00000014285, ENST00000368872.5, OTTHUMT00000034403
    Conserved Domains (1) summary
    cd05168
    Location:514801
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  2. NM_001198774.1NP_001185703.1  phosphatidylinositol 4-kinase beta isoform 2

    See identical proteins and their annotated locations for NP_001185703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two separated exons in the 5' region, as compared to variant 2. The resulting isoform (2) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AB005910, AL391069, BC040300
    Consensus CDS
    CCDS55638.1
    UniProtKB/Swiss-Prot
    Q9UBF8
    Related
    ENSP00000357868.4, OTTHUMP00000014283, ENST00000368874.8, OTTHUMT00000034401
    Conserved Domains (1) summary
    cd05168
    Location:514801
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  3. NM_001198775.2NP_001185704.1  phosphatidylinositol 4-kinase beta isoform 3

    See identical proteins and their annotated locations for NP_001185704.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three consecutive exons in the 5' region, as compared to variant 1. The resulting in isoform (3) has a much shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK294606, AL391069, BC000029, BC040300, DC350175, DC365634
    Consensus CDS
    CCDS55637.1
    UniProtKB/Swiss-Prot
    Q9UBF8
    Related
    ENSP00000433149.1, OTTHUMP00000230728, ENST00000529142.5, OTTHUMT00000316335
    Conserved Domains (1) summary
    cd05168
    Location:197484
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  4. NM_001330721.1NP_001317650.1  phosphatidylinositol 4-kinase beta isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL391069, KF459527
    Consensus CDS
    CCDS81376.1
    UniProtKB/Swiss-Prot
    Q9UBF8
  5. NM_002651.3NP_002642.1  phosphatidylinositol 4-kinase beta isoform 1

    See identical proteins and their annotated locations for NP_002642.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB005910, AK311292, AL391069, BC040300
    Consensus CDS
    CCDS993.1
    UniProtKB/Swiss-Prot
    Q9UBF8
    UniProtKB/TrEMBL
    A0A0B4J1S8
    Related
    ENSP00000357869.2, OTTHUMP00000014284, ENST00000368875.6, OTTHUMT00000034402
    Conserved Domains (1) summary
    cd05168
    Location:541828
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    151291797..151327715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001487.1XP_016856976.1  phosphatidylinositol 4-kinase beta isoform X4

  2. XM_017001490.1XP_016856979.1  phosphatidylinositol 4-kinase beta isoform X5

    UniProtKB/Swiss-Prot
    Q9UBF8
    Related
    ENSP00000357867.1, OTTHUMP00000014282, ENST00000368873.5, OTTHUMT00000034400
    Conserved Domains (1) summary
    cd05168
    Location:529816
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  3. XM_011509636.2XP_011507938.1  phosphatidylinositol 4-kinase beta isoform X2

    See identical proteins and their annotated locations for XP_011507938.1

    Conserved Domains (1) summary
    cd05168
    Location:529837
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  4. XM_017001492.1XP_016856981.1  phosphatidylinositol 4-kinase beta isoform X7

    UniProtKB/Swiss-Prot
    Q9UBF8
    Conserved Domains (1) summary
    cd05168
    Location:514801
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  5. XM_017001488.1XP_016856977.1  phosphatidylinositol 4-kinase beta isoform X4

  6. XM_017001491.1XP_016856980.1  phosphatidylinositol 4-kinase beta isoform X5

    UniProtKB/Swiss-Prot
    Q9UBF8
    Conserved Domains (1) summary
    cd05168
    Location:529816
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  7. XM_011509637.2XP_011507939.1  phosphatidylinositol 4-kinase beta isoform X2

    See identical proteins and their annotated locations for XP_011507939.1

    Conserved Domains (1) summary
    cd05168
    Location:529837
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  8. XM_005245264.3XP_005245321.1  phosphatidylinositol 4-kinase beta isoform X6

    Conserved Domains (1) summary
    cd05168
    Location:526813
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  9. XM_011509638.1XP_011507940.1  phosphatidylinositol 4-kinase beta isoform X3

    Conserved Domains (1) summary
    cd05168
    Location:526834
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  10. XM_011509634.1XP_011507936.1  phosphatidylinositol 4-kinase beta isoform X1

    Conserved Domains (1) summary
    cd05168
    Location:541849
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  11. XM_017001486.1XP_016856975.1  phosphatidylinositol 4-kinase beta isoform X4

  12. XM_011509635.1XP_011507937.1  phosphatidylinositol 4-kinase beta isoform X2

    See identical proteins and their annotated locations for XP_011507937.1

    Conserved Domains (1) summary
    cd05168
    Location:529837
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
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