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PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [ Homo sapiens (human) ]

Gene ID: 5294, updated on 6-Sep-2021

Summary

Official Symbol
PIK3CGprovided by HGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:8978
See related
Ensembl:ENSG00000105851 MIM:601232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI3K; PIK3; PI3CG; PI3Kgamma; p110gamma; p120-PI3K
Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]
Expression
Broad expression in bone marrow (RPKM 12.4), lymph node (RPKM 9.1) and 18 other tissues See more
Orthologs
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Genomic context

See PIK3CG in Genome Data Viewer
Location:
7q22.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (106865282..106908980)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (106505727..106549425)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6701 Neighboring gene long intergenic non-protein coding RNA 2577 Neighboring gene RNA, 5S ribosomal pseudogene 236 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4040 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4041

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
GeneReviews: Not available
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
GeneReviews: Not available
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
GeneReviews: Not available
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
GeneReviews: Not available
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
GeneReviews: Not available
New gene functions in megakaryopoiesis and platelet formation.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphoinositide-3-kinase, catalytic, gamma polypeptide (PIK3CG) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
Nef nef HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively PubMed
nef HIV-1 Nef activation of AKT1 is mediated by PI3K in peripheral blood lymphocytes PubMed
nef HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression PubMed
nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
Tat tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta, leading to activation of PI3K and AKT and inactivation of PTEN and GSK-3beta in vIL-6 expressing cells PubMed
tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
tat Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed
tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed
Vpr vpr HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
vpr HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in adaptive immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in mast cell degranulation TAS
Traceable Author Statement
more info
PubMed 
involved_in natural killer cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cardiac muscle contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in neutrophil extravasation TAS
Traceable Author Statement
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in platelet aggregation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell adhesion mediated by integrin TAS
Traceable Author Statement
more info
PubMed 
involved_in respiratory burst involved in defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in secretory granule localization IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Names
1-phosphatidylinositol 3-kinase
PI3-kinase subunit gamma
phosphatidylinositol 3 kinase gamma, p110 gamma
phosphatidylinositol 3-kinase catalytic 110-kD gamma
phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
phosphoinositide-3-kinase gamma catalytic subunit
ptdIns-3-kinase subunit gamma
ptdIns-3-kinase subunit p110-gamma
serine/threonine protein kinase PIK3CG
NP_001269355.1
NP_001269356.1
NP_002640.2
XP_005250500.1
XP_011514618.1
XP_011514619.1
XP_016867817.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050579.1 RefSeqGene

    Range
    5005..48703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282426.2NP_001269355.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    See identical proteins and their annotated locations for NP_001269355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AA810265, AC005018, AK292684, BC035683, BX648341, X83368
    Consensus CDS
    CCDS5739.1
    UniProtKB/Swiss-Prot
    P48736
    UniProtKB/TrEMBL
    A0A024R720, A8K9G9
    Related
    ENSP00000419260.1, ENST00000496166.6
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
  2. NM_001282427.2NP_001269356.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    See identical proteins and their annotated locations for NP_001269356.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AA810265, AC005018, AK292684, BC035683, X83368
    Consensus CDS
    CCDS5739.1
    UniProtKB/Swiss-Prot
    P48736
    UniProtKB/TrEMBL
    A0A024R720, A8K9G9
    Related
    ENSP00000392258.2, ENST00000440650.6
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
  3. NM_002649.3NP_002640.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    See identical proteins and their annotated locations for NP_002640.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AA810265, AC005018, BC035683, X83368
    Consensus CDS
    CCDS5739.1
    UniProtKB/Swiss-Prot
    P48736
    UniProtKB/TrEMBL
    A0A024R720
    Related
    ENSP00000352121.3, ENST00000359195.3
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    106865282..106908980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516316.1XP_011514618.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X3

    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cl21453
    Location:7291011
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017012328.1XP_016867817.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

  3. XM_011516317.1XP_011514619.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X4

    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cl21453
    Location:729876
    PKc_like; Protein Kinases, catalytic domain
  4. XM_005250443.3XP_005250500.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_005250500.1

    UniProtKB/Swiss-Prot
    P48736
    UniProtKB/TrEMBL
    A0A024R720
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
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