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CBL Cbl proto-oncogene [ Bos taurus (domestic cattle) ]

Gene ID: 527418, updated on 30-Jan-2025
Official Symbol
CBLprovided by VGNC
Official Full Name
Cbl proto-oncogeneprovided by VGNC
Primary source
VGNC:VGNC:26808
See related
BGD:BT12046; EnsemblRapid:ENSBTAG00070029814
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
c-cbl-like
Orthologs
human mouse all
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See CBL in Genome Data Viewer
Location:
chromosome: 15
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29787161..29886490)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene NHERF family PDZ scaffold protein 4 Neighboring gene coiled-coil domain containing 153 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC132342318 Neighboring gene melanoma cell adhesion molecule

Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
E3 ubiquitin-protein ligase CBL
Names
Cas-Br-M ecotropic retroviral transforming sequence
XP_002693128.3
XP_010810819.2

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    29787161..29886490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002693082.6 → XP_002693128.3  E3 ubiquitin-protein ligase CBL isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LN00, A0AAA9S497
    Related
    ENSBTAP00070041278.1, ENSBTAT00070067609.1
    Conserved Domains (6) summary
    cd09920
    Location:254 → 350
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:886 → 922
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    pfam02262
    Location:52 → 173
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:177 → 260
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:360 → 425
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cl26464
    Location:498 → 838
    Atrophin-1; Atrophin-1 family

  2. XM_010812517.4 → XP_010810819.2  E3 ubiquitin-protein ligase CBL isoform X2

    UniProtKB/TrEMBL
    A0AAA9S497, E1BJS3
    Related
    ENSBTAP00070041301.1, ENSBTAT00070067643.1
    Conserved Domains (6) summary
    cd09920
    Location:254 → 350
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:866 → 902
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    pfam02262
    Location:52 → 173
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:177 → 260
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:360 → 425
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cl26464
    Location:478 → 818
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version

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