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SERPINB10 serpin family B member 10 [ Homo sapiens (human) ]

Gene ID: 5273, updated on 13-Mar-2020

Summary

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Official Symbol
SERPINB10provided by HGNC
Official Full Name
serpin family B member 10provided by HGNC
Primary source
HGNC:HGNC:8942
See related
Ensembl:ENSG00000242550 MIM:602058
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI10; PI-10
Summary
This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward bone marrow (RPKM 23.0) See more
Orthologs
mouse all

Genomic context

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See SERPINB10 in Genome Data Viewer
Location:
18q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (63907958..63936111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61575224..61602948)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene serpin family B member 7 Neighboring gene serpin family B member 2 Neighboring gene uncharacterized LOC105372165 Neighboring gene Sharpr-MPRA regulatory region 9998 Neighboring gene histocompatibility minor serpin domain containing Neighboring gene serpin family B member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment. Przygodzka P, et al. BMC Cell Biol, 2010 Apr 30. PMID 20433722, Free PMC Article
  2. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. Schleef RR, et al. J Biol Chem, 2000 Aug 25. PMID 10871600
  3. Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10. Chuang TL, et al. J Biol Chem, 1999 Apr 16. PMID 10196205
  4. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. Riewald M, et al. J Biol Chem, 1995 Nov 10. PMID 7592909
  5. Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation. Mo Y, et al. Am J Physiol Lung Cell Mol Physiol, 2019 Jan 1. PMID 30382768

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epithelial SERPINB10 contributes to allergic airway eosinophilic inflammation, at least in part, by regulating the expression of periostin and CCL26.
    Title: Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation.
  2. DGCR2, GPR44 and SerpinB10, found in beta cells, were negative in all other cell types within pancreas and exposed epitopes at the cell surface
    Title: Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates.
  3. Bomapin is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability.
    Title: Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
  
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  
plasma membrane TAS
Traceable Author Statement
more info
  
secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
serpin B10
Names
bomapin
peptidase inhibitor 10
protease inhibitor 10 (ovalbumin type, bomapin)
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10
serpin peptidase inhibitor, clade B (ovalbumin), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005024.3 → NP_005015.1  serpin B10

    See identical proteins and their annotated locations for NP_005015.1

    Status: REVIEWED

    Source sequence(s)
    AA993220, AC009802, AC072051, AK314936, U35459
    Consensus CDS
    CCDS11990.1
    UniProtKB/Swiss-Prot
    P48595
    UniProtKB/TrEMBL
    B2RC45
    Related
    ENSP00000238508.3, ENST00000238508.8
    Conserved Domains (1) summary
    cd02058
    Location:4 → 397
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    63907958..63936111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526027.1 → XP_011524329.1  serpin B10 isoform X1

    See identical proteins and their annotated locations for XP_011524329.1

    UniProtKB/Swiss-Prot
    P48595
    Conserved Domains (1) summary
    cd02058
    Location:4 → 397
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

  2. XM_017025793.1 → XP_016881282.1  serpin B10 isoform X2

  3. XM_017025794.1 → XP_016881283.1  serpin B10 isoform X4

  4. XM_011526028.1 → XP_011524330.1  serpin B10 isoform X3

    Conserved Domains (1) summary
    cl00137
    Location:1 → 268
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48595.1 GenPept UniProtKB/Swiss-Prot:P48595

Gene LinkOut

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