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BECN1 beclin 1 [ Bos taurus (cattle) ]

Gene ID: 527278, updated on 17-Sep-2018

Summary

Official Symbol
BECN1provided by VGNC
Official Full Name
beclin 1provided by VGNC
Primary source
VGNC:VGNC:26463
See related
BGD:BT26123; Ensembl:ENSBTAG00000019914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ATG6
Orthologs

Genomic context

See BECN1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 19 NC_037346.1 (42837030..42848132, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 19 AC_000176.1 (43479253..43489432, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene cytochrome c oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene proteasome activator subunit 3 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene amine oxidase, copper containing 2

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
    Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis - multiple species, conserved biosystem (from KEGG)
    Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - other, organism-specific biosystem (from KEGG)
    Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - other, conserved biosystem (from KEGG)
    Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Clone Names

  • MGC126978

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
early endosome to late endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
engulfment of apoptotic cell IEA
Inferred from Electronic Annotation
more info
 
lysosome organization IEA
Inferred from Electronic Annotation
more info
 
macroautophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
mitophagy IEA
Inferred from Electronic Annotation
more info
 
mitotic metaphase plate congression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of attachment of mitotic spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to mitochondrial depolarisation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
autophagosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase complex, class III ISS
Inferred from Sequence or Structural Similarity
more info
 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beclin-1
Names
beclin 1, autophagy related
coiled-coil myosin-like BCL2-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033627.2NP_001028799.1  beclin-1

    See identical proteins and their annotated locations for NP_001028799.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102177
    UniProtKB/Swiss-Prot
    Q4A1L4
    Related
    ENSBTAP00000026531.4, ENSBTAT00000026531.4
    Conserved Domains (2) summary
    pfam15285
    Location:105127
    BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    pfam04111
    Location:133443
    APG6; Autophagy protein Apg6

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    42837030..42848132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024980228.1XP_024835996.1  beclin-1 isoform X1

    Conserved Domains (2) summary
    pfam15285
    Location:128150
    BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    pfam04111
    Location:156466
    APG6; Autophagy protein Apg6
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