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FYN FYN proto-oncogene, Src family tyrosine kinase [ Bos taurus (domestic cattle) ]

Gene ID: 527263, updated on 5-Sep-2025
Official Symbol
FYNprovided by VGNC
Official Full Name
FYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:29163
See related
BGD:BT11590; EnsemblRapid:ENSBTAG00070005297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See FYN in Genome Data Viewer
Location:
chromosome: 9
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (38568874..38780960)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene tubulin epsilon 1 Neighboring gene cellular communication network factor 6 Neighboring gene uncharacterized LOC112448036 Neighboring gene uncharacterized LOC132346163 Neighboring gene TRAF3 interacting protein 2 Neighboring gene gametogenetin

Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Regulation of the bovine kidney microsomal chloride channel p64 by p59fyn, a Src family tyrosine kinase. Edwards JC, et al. J Biol Chem, 2000 Oct 13. PMID 10930415
  2. Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation. Chiu YJ, et al. J Cell Biol, 2008 Aug 25. PMID 18710921, Free PMC Article
  3. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. Sontag JM, et al. J Biol Chem, 2012 Apr 27. PMID 22403409, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
    Title: The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
  2. PECAM-1 and Fyn are essential components of a PECAM-1-based mechanosensory complex in endothelial cells.
    Title: Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase Fyn
Names
FYN oncogene related to SRC, FGR, YES
p59-Fyn
protein-tyrosine kinase fyn
proto-oncogene c-Fyn
proto-oncogene tyrosine-protein kinase Fyn
NP_001071440.1
XP_005210845.1
XP_005210846.1
XP_005210848.1
XP_010806740.1
XP_059745713.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077972.1 → NP_001071440.1  tyrosine-protein kinase Fyn

    See identical proteins and their annotated locations for NP_001071440.1

    Status: PROVISIONAL

    Source sequence(s)
    BC126591
    UniProtKB/Swiss-Prot
    A0JNB0
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    38568874..38780960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005210788.4 → XP_005210845.1  tyrosine-protein kinase Fyn isoform X1

    See identical proteins and their annotated locations for XP_005210845.1

    UniProtKB/Swiss-Prot
    A0JNB0
    Related
    ENSBTAP00070006821.1, ENSBTAT00070012094.1
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  2. XM_005210791.4 → XP_005210848.1  tyrosine-protein kinase Fyn isoform X2

    See identical proteins and their annotated locations for XP_005210848.1

    UniProtKB/TrEMBL
    A0AAA9TBK8
    Related
    ENSBTAP00070006820.1, ENSBTAT00070012088.1
    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258 → 531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  3. XM_010808438.4 → XP_010806740.1  tyrosine-protein kinase Fyn isoform X3

    See identical proteins and their annotated locations for XP_010806740.1

    UniProtKB/TrEMBL
    A0AAA9T264
    Related
    ENSBTAP00070006823.1, ENSBTAT00070012098.1
    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cl21453
    Location:231 → 467
    PKc_like; Protein Kinases, catalytic domain

  4. XM_005210789.5 → XP_005210846.1  tyrosine-protein kinase Fyn isoform X1

    See identical proteins and their annotated locations for XP_005210846.1

    UniProtKB/Swiss-Prot
    A0JNB0
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  5. XM_059889730.1 → XP_059745713.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/Swiss-Prot
    A0JNB0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JNB0.1 GenPept UniProtKB/Swiss-Prot:A0JNB0

Gene LinkOut

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