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SERPINB9 serpin family B member 9 [ Homo sapiens (human) ]

Gene ID: 5272, updated on 10-May-2020

Summary

Official Symbol
SERPINB9provided by HGNC
Official Full Name
serpin family B member 9provided by HGNC
Primary source
HGNC:HGNC:8955
See related
Ensembl:ENSG00000170542 MIM:601799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI9; CAP3; PI-9; CAP-3
Summary
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]
Expression
Broad expression in placenta (RPKM 26.1), appendix (RPKM 19.1) and 21 other tissues See more
Orthologs

Genomic context

See SERPINB9 in Genome Data Viewer
Location:
6p25.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (2887270..2903318, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (2887499..2903546, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 71 enhancer Neighboring gene serpin family B member 9 pseudogene 1 Neighboring gene microRNA 4645 Neighboring gene uncharacterized LOC101927730 Neighboring gene uncharacterized LOC105374887 Neighboring gene serpin family B member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serpin B9
Names
cytoplasmic antiproteinase 3
peptidase inhibitor 9
protease inhibitor 9 (ovalbumin type)
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
serpin peptidase inhibitor, clade B, member 9
testicular tissue protein Li 180

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004155.6NP_004146.1  serpin B9

    See identical proteins and their annotated locations for NP_004146.1

    Status: REVIEWED

    Source sequence(s)
    AL133351, BC002538, BX485378
    Consensus CDS
    CCDS4478.1
    UniProtKB/Swiss-Prot
    P50453
    UniProtKB/TrEMBL
    A0A024QZT4
    Related
    ENSP00000370074.4, ENST00000380698.5
    Conserved Domains (1) summary
    cl00137
    Location:4376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    2887270..2903318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010942.1XP_016866431.1  serpin B9 isoform X2

    Conserved Domains (1) summary
    cl00137
    Location:13325
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. XM_017010943.1XP_016866432.1  serpin B9 isoform X2

    Conserved Domains (1) summary
    cl00137
    Location:13325
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  3. XM_011514678.2XP_011512980.1  serpin B9 isoform X2

    See identical proteins and their annotated locations for XP_011512980.1

    Conserved Domains (1) summary
    cl00137
    Location:13325
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  4. XM_005249184.5XP_005249241.1  serpin B9 isoform X1

    See identical proteins and their annotated locations for XP_005249241.1

    UniProtKB/Swiss-Prot
    P50453
    UniProtKB/TrEMBL
    A0A024QZT4
    Conserved Domains (1) summary
    cl00137
    Location:4376
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
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