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Zkscan6 zinc finger with KRAB and SCAN domains 6 [ Mus musculus (house mouse) ]

Gene ID: 52712, updated on 2-Oct-2018

Summary

Official Symbol
Zkscan6provided by MGI
Official Full Name
zinc finger with KRAB and SCAN domains 6provided by MGI
Primary source
MGI:MGI:1289293
See related
Ensembl:ENSMUSG00000018347 Vega:OTTMUSG00000005906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KOX11; Znf18; Zfp535; D11Ertd714e; 1700128E15Rik
Expression
Ubiquitous expression in testis adult (RPKM 3.6), CNS E18 (RPKM 2.9) and 28 other tissues See more
Orthologs

Genomic context

See Zkscan6 in Genome Data Viewer
Location:
11 B3; 11 40.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (65807175..65829239)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (65620746..65642741)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30786 Neighboring gene predicted gene, 40026 Neighboring gene mitogen-activated protein kinase kinase 4 Neighboring gene microRNA 744 Neighboring gene dynein, axonemal, heavy chain 9 Neighboring gene predicted gene, 40027 Neighboring gene predicted gene, 45917 Neighboring gene shisa family member 6 Neighboring gene predicted gene, 45945

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 18
Names
zinc finger protein 535
zinc finger protein with KRAB and SCAN domains 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302374.1NP_001289303.1  zinc finger protein 18 isoform 1

    See identical proteins and their annotated locations for NP_001289303.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK007308, AL596025, BC043075, BY224975
    Consensus CDS
    CCDS24845.1
    UniProtKB/Swiss-Prot
    Q810A1
    Related
    ENSMUSP00000071406.2, OTTMUSP00000006104, ENSMUST00000071465.8, OTTMUST00000013150
    Conserved Domains (7) summary
    smart00431
    Location:37144
    SCAN; leucine rich region
    cd07765
    Location:229256
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:428541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:443465
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:37125
    SCAN; SCAN domain
    pfam13465
    Location:513537
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001302375.1NP_001289304.1  zinc finger protein 18 isoform 2

    See identical proteins and their annotated locations for NP_001289304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK007308, AL596025, BC043075, BY224975
    UniProtKB/Swiss-Prot
    Q810A1
    Conserved Domains (4) summary
    COG5048
    Location:427540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:229277
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cl02605
    Location:37144
    SCAN; SCAN oligomerization domain
  3. NM_001362834.1NP_001349763.1  zinc finger protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI646524, AL596025
    Conserved Domains (4) summary
    COG5048
    Location:427540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:229277
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cl02605
    Location:37144
    SCAN; SCAN oligomerization domain
  4. NM_026107.3NP_080383.2  zinc finger protein 18 isoform 1

    See identical proteins and their annotated locations for NP_080383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK007308, BC043075, BY224975
    Consensus CDS
    CCDS24845.1
    UniProtKB/Swiss-Prot
    Q810A1
    Related
    ENSMUSP00000018491.7, OTTMUSP00000006103, ENSMUST00000018491.7, OTTMUST00000013149
    Conserved Domains (7) summary
    smart00431
    Location:37144
    SCAN; leucine rich region
    cd07765
    Location:229256
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:428541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:443465
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:37125
    SCAN; SCAN domain
    pfam13465
    Location:513537
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    65807175..65829239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533717.3XP_006533780.1  zinc finger protein 18 isoform X1

    See identical proteins and their annotated locations for XP_006533780.1

    UniProtKB/Swiss-Prot
    Q810A1
    Conserved Domains (7) summary
    smart00431
    Location:37144
    SCAN; leucine rich region
    cd07765
    Location:229256
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:428541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:443465
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:37125
    SCAN; SCAN domain
    pfam13465
    Location:513537
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017314660.1XP_017170149.1  zinc finger protein 18 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:427540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:229277
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cl02605
    Location:37144
    SCAN; SCAN oligomerization domain
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