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ATP6V0C ATPase H+ transporting V0 subunit c [ Homo sapiens (human) ]

Gene ID: 527, updated on 18-Aug-2020

Summary

Official Symbol
ATP6V0Cprovided by HGNC
Official Full Name
ATPase H+ transporting V0 subunit cprovided by HGNC
Primary source
HGNC:HGNC:855
See related
Ensembl:ENSG00000185883 MIM:108745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPL; VATL; VPPC; Vma3; ATP6C; ATP6L
Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in kidney (RPKM 126.5), brain (RPKM 117.6) and 25 other tissues See more
Orthologs

Genomic context

See ATP6V0C in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2513726..2520218)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2563727..2570224)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene netrin 3 Neighboring gene TBC1 domain family member 24 Neighboring gene amidohydrolase domain containing 2 Neighboring gene microRNA 3178 Neighboring gene cementum protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (ATP6V0C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proton-transporting ATP synthase activity, rotational mechanism TAS
Traceable Author Statement
more info
PubMed 
proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phagosome acidification TAS
Traceable Author Statement
more info
 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy NAS
Non-traceable Author Statement
more info
PubMed 
transferrin transport TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane HDA PubMed 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
V-type proton ATPase 16 kDa proteolipid subunit
Names
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
H(+)-transporting two-sector ATPase, 16 kDa subunit
V-ATPase 16 kDa proteolipid subunit
vacuolar ATP synthase 16 kDa proteolipid subunit
vacuolar H+ ATPase proton channel subunit
vacuolar proton pump 16 kDa proteolipid subunit
NP_001185498.1
NP_001685.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198569.2NP_001185498.1  V-type proton ATPase 16 kDa proteolipid subunit

    See identical proteins and their annotated locations for NP_001185498.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093525, AW161158, BC009290
    Consensus CDS
    CCDS10470.1
    UniProtKB/Swiss-Prot
    P27449
    Conserved Domains (2) summary
    TIGR01100
    Location:13118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    pfam00137
    Location:93152
    ATP-synt_C; ATP synthase subunit C
  2. NM_001694.4NP_001685.1  V-type proton ATPase 16 kDa proteolipid subunit

    See identical proteins and their annotated locations for NP_001685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093525, BC009290
    Consensus CDS
    CCDS10470.1
    UniProtKB/Swiss-Prot
    P27449
    Related
    ENSP00000329757.4, ENST00000330398.9
    Conserved Domains (2) summary
    TIGR01100
    Location:13118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    pfam00137
    Location:93152
    ATP-synt_C; ATP synthase subunit C

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2513726..2520218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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