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Esyt2 extended synaptotagmin-like protein 2 [ Mus musculus (house mouse) ]

Gene ID: 52635, updated on 12-May-2024

Summary

Official Symbol
Esyt2provided by MGI
Official Full Name
extended synaptotagmin-like protein 2provided by MGI
Primary source
MGI:MGI:1261845
See related
Ensembl:ENSMUSG00000021171 AllianceGenome:MGI:1261845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam62b; CHR2SYT; D12Ertd551e; 2410017M09Rik; 4921504I16Rik
Summary
Predicted to enable calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering. Predicted to act upstream of or within endocytosis and lipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be integral component of plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including aorta; genitourinary system; mammary gland; nervous system; and retina. Orthologous to human ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
Orthologs
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Genomic context

See Esyt2 in Genome Data Viewer
Location:
12 F2; 12 62.65 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116242903..116354555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116279283..116390935)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10777 Neighboring gene predicted gene, 46330 Neighboring gene dynein 2 intermediate chain 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:117519461-117519695 Neighboring gene RIKEN cDNA 2310058N22 gene Neighboring gene RIKEN cDNA D430020J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4047 Neighboring gene non-SMC condensin II complex, subunit G2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1228

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum-plasma membrane tethering IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
extended synaptotagmin-2
Names
E-Syt2
chr2 synaptotagmin
family with sequence similarity 62 (C2 domain containing), member B
family with sequence similarity 62, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028731.5NP_083007.2  extended synaptotagmin-2

    See identical proteins and their annotated locations for NP_083007.2

    Status: VALIDATED

    Source sequence(s)
    AI838753, AK014813, AK044360, BC059230
    Consensus CDS
    CCDS26211.1
    UniProtKB/Swiss-Prot
    B2RSN5, Q3TZZ7, Q9D5Y7
    Related
    ENSMUSP00000098548.3, ENSMUST00000100986.4
    Conserved Domains (4) summary
    cd04030
    Location:710835
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:461566
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    116242903..116354555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246808.1XP_030102668.1  extended synaptotagmin-2 isoform X2

    Conserved Domains (4) summary
    cd04030
    Location:744869
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:461600
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
  2. XM_017315129.2XP_017170618.1  extended synaptotagmin-2 isoform X1

    Conserved Domains (4) summary
    cd04030
    Location:744864
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:461600
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
  3. XM_011244139.3XP_011242441.1  extended synaptotagmin-2 isoform X3

    Conserved Domains (4) summary
    cd04030
    Location:731851
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:461587
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
  4. XM_030246810.1XP_030102670.1  extended synaptotagmin-2 isoform X5

    Conserved Domains (4) summary
    cd04030
    Location:710830
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:461566
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
  5. XM_036157525.1XP_036013418.1  extended synaptotagmin-2 isoform X2

    Conserved Domains (4) summary
    cd04030
    Location:744869
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:461600
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
  6. XM_006516075.4XP_006516138.1  extended synaptotagmin-2 isoform X7

    Conserved Domains (2) summary
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
  7. XM_036157526.1XP_036013419.1  extended synaptotagmin-2 isoform X8

    Conserved Domains (2) summary
    cd08391
    Location:309429
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:115294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
  8. XM_017315131.1XP_017170620.1  extended synaptotagmin-2 isoform X6

    Conserved Domains (4) summary
    cd04030
    Location:578698
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:295434
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:143263
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:4128
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

RNA

  1. XR_003950062.1 RNA Sequence

  2. XR_003950063.1 RNA Sequence

  3. XR_004937526.1 RNA Sequence

  4. XR_004937527.1 RNA Sequence