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Suz12 SUZ12 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 52615, updated on 8-Dec-2022

Summary

Official Symbol
Suz12provided by MGI
Official Full Name
SUZ12 polycomb repressive complex 2 subunitprovided by MGI
Primary source
MGI:MGI:1261758
See related
Ensembl:ENSMUSG00000017548 AllianceGenome:MGI:1261758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0160; D11Ertd530e; 2610028O16Rik
Summary
This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Expression
Broad expression in liver E14 (RPKM 18.5), CNS E11.5 (RPKM 16.1) and 25 other tissues See more
Orthologs
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Genomic context

See Suz12 in Genome Data Viewer
Location:
11 B5; 11 47.36 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79883932..79924949)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79993106..80034123)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene UTP6 small subunit processome component Neighboring gene predicted gene, 30875 Neighboring gene cytokine receptor-like factor 3 Neighboring gene ATPase family, AAA domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0160

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dosage compensation by inactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facultative heterochromatin formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histone H3-K27 trimethylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within histone ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
part_of RSC-type complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in sex chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycomb protein Suz12
Names
suppressor of zeste 12 homolog
suppressor of zeste 12 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163018.1NP_001156490.1  polycomb protein Suz12 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK076010, BC064461
    Consensus CDS
    CCDS48860.1
    UniProtKB/Swiss-Prot
    Q80U70
    UniProtKB/TrEMBL
    E9PW15
    Related
    ENSMUSP00000126932.2, ENSMUST00000163272.2
    Conserved Domains (1) summary
    pfam09733
    Location:525659
    VEFS-Box; VEFS-Box of polycomb protein
  2. NM_199196.2NP_954666.1  polycomb protein Suz12 isoform 1

    See identical proteins and their annotated locations for NP_954666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK076010, BC064461
    Consensus CDS
    CCDS25125.1
    UniProtKB/Swiss-Prot
    Q80U70, Q99L07
    Related
    ENSMUSP00000017692.9, ENSMUST00000017692.15
    Conserved Domains (1) summary
    pfam09733
    Location:548682
    VEFS-Box; VEFS-Box of polycomb protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79883932..79924949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)