CBLB Cbl proto-oncogene B [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CBLBprovided by VGNC
Official Full Name: Cbl proto-oncogene Bprovided by VGNC
Primary source: VGNC:VGNC:26809
See related: BGD:BT17932; EnsemblRapid:ENSBTAG00070000823
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	1	NC_037328.1 (50255480..50481343, complement)

Chromosome 1 - NC_037328.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info	PubMed
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of epidermal growth factor-activated receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: E3 ubiquitin-protein ligase CBL-B

Names: Cas-Br-M ecotropic retroviral transforming sequence b

NP_001192852.1

EC 2.3.2.27

XP_005201373.1

EC 2.3.2.27

XP_005201374.1

EC 2.3.2.27

XP_010799403.1

EC 2.3.2.27

XP_010799404.1

EC 2.3.2.27

XP_010799406.1

EC 2.3.2.27

XP_024845499.1

EC 2.3.2.27

XP_024845502.1

EC 2.3.2.27

XP_024845506.1

EC 2.3.2.27

XP_024845508.1

EC 2.3.2.27

XP_059740826.1

EC 2.3.2.27

XP_059740836.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205923.2 → NP_001192852.1 E3 ubiquitin-protein ligase CBL-B

See identical proteins and their annotated locations for NP_001192852.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000001

UniProtKB/TrEMBL

A0A3Q1LUB2, F1N510, G3N0D7

Related

ENSBTAP00070001029.1, ENSBTAT00070001931.1

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd00162
Location:373 → 415

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14392
Location:932 → 972

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

Range

50255480..50481343 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024989738.2 → XP_024845506.1 E3 ubiquitin-protein ligase CBL-B isoform X6

UniProtKB/TrEMBL

G3N0D7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:810 → 850

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_024989734.2 → XP_024845502.1 E3 ubiquitin-protein ligase CBL-B isoform X5

UniProtKB/TrEMBL

G3N0D7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:839 → 879

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_024989731.2 → XP_024845499.1 E3 ubiquitin-protein ligase CBL-B isoform X4

UniProtKB/TrEMBL

G3N0D7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:883 → 923

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_010801104.4 → XP_010799406.1 E3 ubiquitin-protein ligase CBL-B isoform X2

UniProtKB/TrEMBL

A0A3Q1LZ97, G3N0D7

Related

ENSBTAP00070001026.1, ENSBTAT00070001921.1

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd00162
Location:373 → 415

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14392
Location:888 → 928

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_059884843.1 → XP_059740826.1 E3 ubiquitin-protein ligase CBL-B isoform X3

UniProtKB/TrEMBL

G3N0D7
XM_005201316.5 → XP_005201373.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_005201373.1

UniProtKB/TrEMBL

A0A3Q1LUB2, F1N510, G3N0D7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd00162
Location:373 → 415

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14392
Location:932 → 972

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_010801102.4 → XP_010799404.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_010799404.1

UniProtKB/TrEMBL

A0A3Q1LUB2, F1N510, G3N0D7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd00162
Location:373 → 415

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14392
Location:932 → 972

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_024989740.2 → XP_024845508.1 E3 ubiquitin-protein ligase CBL-B isoform X4

UniProtKB/TrEMBL

G3N0D7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:883 → 923

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_005201317.5 → XP_005201374.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_005201374.1

UniProtKB/TrEMBL

A0A3Q1LUB2, F1N510, G3N0D7

Related

ENSBTAP00070001021.1, ENSBTAT00070001909.1

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd00162
Location:373 → 415

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14392
Location:932 → 972

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_010801101.4 → XP_010799403.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_010799403.1

UniProtKB/TrEMBL

A0A3Q1LUB2, F1N510, G3N0D7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd00162
Location:373 → 415

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14392
Location:932 → 972

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_059884853.1 → XP_059740836.1 E3 ubiquitin-protein ligase CBL-B isoform X7

UniProtKB/TrEMBL

G3N0D7