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AGRN agrin [ Bos taurus (domestic cattle) ]

Gene ID: 525795, updated on 30-Jan-2025
Official Symbol
AGRNprovided by VGNC
Official Full Name
agrinprovided by VGNC
Primary source
VGNC:VGNC:25742
See related
BGD:BT28664; EnsemblRapid:ENSBTAG00070020736
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See AGRN in Genome Data Viewer
Location:
chromosome: 16
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (51422630..51461881, complement)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 223 Neighboring gene tyrosine-protein phosphatase non-receptor type 11 Neighboring gene uncharacterized LOC104974468 Neighboring gene ISG15 ubiquitin like modifier Neighboring gene hes family bHLH transcription factor 4

Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane. Yamada H, et al. J Biol Chem, 1996 Sep 20. PMID 8798547
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
agrin

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    51422630..51461881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002694193.6 → XP_002694239.1  agrin isoform X2

    See identical proteins and their annotated locations for XP_002694239.1

    UniProtKB/TrEMBL
    A0AAA9TR62
    Related
    ENSBTAP00070028218.1, ENSBTAT00070047164.1
    Conserved Domains (7) summary
    smart00280
    Location:492 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1130 → 1254
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1819 → 1851
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1666 → 1797
    Laminin_G_1; Laminin G domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  2. XM_005217205.5 → XP_005217262.1  agrin isoform X1

    See identical proteins and their annotated locations for XP_005217262.1

    UniProtKB/TrEMBL
    F1MSI2
    Related
    ENSBTAP00070028256.1, ENSBTAT00070047244.1
    Conserved Domains (7) summary
    smart00280
    Location:492 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1130 → 1254
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1823 → 1855
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1666 → 1801
    Laminin_G_1; Laminin G domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  3. XM_024976824.2 → XP_024832592.1  agrin isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MDW2
    Conserved Domains (7) summary
    smart00280
    Location:385 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1023 → 1147
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1716 → 1748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1559 → 1694
    Laminin_G_1; Laminin G domain
    pfam05956
    Location:1167 → 1228
    APC_basic; APC basic domain

  4. XM_005217206.5 → XP_005217263.1  agrin isoform X3

    See identical proteins and their annotated locations for XP_005217263.1

    UniProtKB/TrEMBL
    A0A3Q1MDW2
    Conserved Domains (6) summary
    smart00280
    Location:385 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1023 → 1147
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1716 → 1748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1559 → 1694
    Laminin_G_1; Laminin G domain
Nucleotide Protein Strain
Heading Accession and Version

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