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Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) [ Mus musculus (house mouse) ]

Gene ID: 52538, updated on 26-Sep-2022

Summary

Official Symbol
Acaa2provided by MGI
Official Full Name
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)provided by MGI
Primary source
MGI:MGI:1098623
See related
Ensembl:ENSMUSG00000036880 AllianceGenome:MGI:1098623
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D18Ertd240e; 0610011L04Rik
Summary
Predicted to enable acetyl-CoA C-acetyltransferase activity and acyl-CoA hydrolase activity. Predicted to be involved in several processes, including cellular response to hypoxia; fatty acid beta-oxidation; and regulation of mitochondrial membrane permeability. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; integumental system; sensory organ; and urinary system. Orthologous to human ACAA2 (acetyl-CoA acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 299.0), heart adult (RPKM 261.9) and 19 other tissues See more
Orthologs
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Genomic context

See Acaa2 in Genome Data Viewer
Location:
18 E2; 18 50.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74912283..74939278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74779212..74806207)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 17 Neighboring gene predicted gene, 41774 Neighboring gene predicted gene, 23119 Neighboring gene predicted gene, 52350 Neighboring gene ribosomal protein L37a, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetyl-CoA C-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acetyl-CoA C-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acetyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-ketoacyl-CoA thiolase, mitochondrial
Names
acetyl-CoA acetyltransferase
acetyl-CoA acyltransferase
acyl-CoA hydrolase, mitochondrial
beta-ketothiolase
mitochondrial 3-oxoacyl-CoA thiolase
NP_803421.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177470.3NP_803421.1  3-ketoacyl-CoA thiolase, mitochondrial

    See identical proteins and their annotated locations for NP_803421.1

    Status: PROVISIONAL

    Source sequence(s)
    AK050101
    Consensus CDS
    CCDS29342.1
    UniProtKB/Swiss-Prot
    Q8BWT1, Q8JZR8
    Related
    ENSMUSP00000037348.10, ENSMUST00000041053.11
    Conserved Domains (1) summary
    cd00751
    Location:8395
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    74912283..74939278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)