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Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) [ Mus musculus (house mouse) ]

Gene ID: 52538, updated on 15-Apr-2019

Summary

Official Symbol
Acaa2provided by MGI
Official Full Name
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)provided by MGI
Primary source
MGI:MGI:1098623
See related
Ensembl:ENSMUSG00000036880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI255831; AI265397; D18Ertd240e; 0610011L04Rik
Expression
Broad expression in liver E18 (RPKM 299.0), heart adult (RPKM 261.9) and 19 other tissues See more
Orthologs

Genomic context

See Acaa2 in Genome Data Viewer
Location:
18 E2; 18 50.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (74779212..74806207)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (74938866..74965861)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene myosin VB Neighboring gene predicted gene, 33090 Neighboring gene small Cajal body-specific RNA 17 Neighboring gene predicted gene, 41774 Neighboring gene ribosomal protein L37a, pseudogene 2 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA C-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane HDA PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-ketoacyl-CoA thiolase, mitochondrial
Names
acetyl-CoA acyltransferase
beta-ketothiolase
mitochondrial 3-oxoacyl-CoA thiolase
NP_803421.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177470.3NP_803421.1  3-ketoacyl-CoA thiolase, mitochondrial

    See identical proteins and their annotated locations for NP_803421.1

    Status: PROVISIONAL

    Source sequence(s)
    AK050101
    Consensus CDS
    CCDS29342.1
    UniProtKB/Swiss-Prot
    Q8BWT1
    Related
    ENSMUSP00000037348.9, ENSMUST00000041053.10
    Conserved Domains (2) summary
    PRK05790
    Location:5393
    PRK05790; putative acyltransferase; Provisional
    cd00751
    Location:8395
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    74779212..74806207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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