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Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 52440, updated on 22-Jan-2023

Summary

Official Symbol
Tax1bp1provided by MGI
Official Full Name
Tax1 (human T cell leukemia virus type I) binding protein 1provided by MGI
Primary source
MGI:MGI:1289308
See related
Ensembl:ENSMUSG00000004535 AllianceGenome:MGI:1289308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T6bp; TXBP151; D6Ertd404e; D6Ertd772e; 1200003J11Rik; 1700069J21Rik
Summary
Enables kinase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 37.5), testis adult (RPKM 35.3) and 27 other tissues See more
Orthologs
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Genomic context

See Tax1bp1 in Genome Data Viewer
Location:
6 B3; 6 25.7 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52690677..52743765)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52713692..52766780)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyrate dehydrogenase Neighboring gene predicted gene, 24355 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene JAZF zinc finger 1 Neighboring gene predicted gene, 52904 Neighboring gene predicted gene, 52903

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tax1-binding protein 1 homolog
Names
TRAF6-binding protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355595.1NP_001342524.1  tax1-binding protein 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC099741, AC117212, BP754065
    Conserved Domains (1) summary
    cl25732
    Location:17398
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001355596.1NP_001342525.1  tax1-binding protein 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC099741, AC117212, BP754065
    Consensus CDS
    CCDS39490.1
    UniProtKB/Swiss-Prot
    Q9DC45
    Conserved Domains (1) summary
    cl25732
    Location:17460
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_025816.3NP_080092.2  tax1-binding protein 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_080092.2

    Status: VALIDATED

    Source sequence(s)
    AC099741, AK146076, BP754065
    Consensus CDS
    CCDS39490.1
    UniProtKB/Swiss-Prot
    Q3UKC1, Q9DC45
    Related
    ENSMUSP00000079548.5, ENSMUST00000080723.11
    Conserved Domains (1) summary
    cl25732
    Location:17460
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    52690677..52743765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506370.5XP_006506433.1  tax1-binding protein 1 homolog isoform X1

    Conserved Domains (4) summary
    COG4372
    Location:338645
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam07888
    Location:125408
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:17120
    SKICH; SKICH domain
    pfam18112
    Location:704730
    Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain