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PGR progesterone receptor [ Homo sapiens (human) ]

Gene ID: 5241, updated on 1-Jun-2020

Summary

Official Symbol
PGRprovided by HGNC
Official Full Name
progesterone receptorprovided by HGNC
Primary source
HGNC:HGNC:8910
See related
Ensembl:ENSG00000082175 MIM:607311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR; NR3C3
Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Expression
Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5) See more
Orthologs

Genomic context

See PGR in Genome Data Viewer
Location:
11q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (101029624..101130681, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (100900355..101000544, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 42 Neighboring gene uncharacterized LOC105369457 Neighboring gene small nucleolar RNA, C/D box 13I Neighboring gene PGR antisense RNA 1 Neighboring gene myotubularin related protein 12 pseudogene Neighboring gene uncharacterized LOC105369458

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Progesterone resistance
MedGen: C1849699 OMIM: 264080 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEP
Inferred from Expression Pattern
more info
PubMed 
ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
 
paracrine signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
progesterone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tertiary branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
progesterone receptor
Names
nuclear receptor subfamily 3 group C member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016475.1 RefSeqGene

    Range
    5001..105190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000926.4NP_000917.3  progesterone receptor isoform B

    See identical proteins and their annotated locations for NP_000917.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (B).
    Source sequence(s)
    AP001533, M15716
    Consensus CDS
    CCDS8310.1
    UniProtKB/Swiss-Prot
    P06401
    Related
    ENSP00000325120.5, ENST00000325455.10
    Conserved Domains (3) summary
    cd07074
    Location:686933
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:563640
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1564
    Prog_receptor; Progesterone receptor
  2. NM_001202474.3NP_001189403.1  progesterone receptor isoform A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses a different promoter than variant 2 and has a transcription initiation site that lies just downstream of the translation start site of variant 2 (see PMID:2328727). The resulting isoform (A) is shorter at the N-terminus compared to isoform B.
    Source sequence(s)
    AP001533, M15716
    UniProtKB/Swiss-Prot
    P06401
    Conserved Domains (3) summary
    cd07074
    Location:522769
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:399476
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1400
    Prog_receptor; Progesterone receptor
  3. NM_001271161.2NP_001258090.1  progesterone receptor isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter isoform (C).
    Source sequence(s)
    AB084248, AP001533
    UniProtKB/Swiss-Prot
    P06401
    Related
    ENSP00000263463.5, ENST00000263463.9
    Conserved Domains (3) summary
    cd07172
    Location:399475
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1400
    Prog_receptor; Progesterone receptor
    cl11397
    Location:470667
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. NM_001271162.2NP_001258091.1  progesterone receptor isoform D

    See identical proteins and their annotated locations for NP_001258091.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents an alternate first exon, compared to variant 1, resulting in a protein isoform (D) with a shorter N-terminus.
    Source sequence(s)
    AK304853, AP001533
    Consensus CDS
    CCDS59229.1
    UniProtKB/Swiss-Prot
    P06401
    Related
    ENSP00000436561.1, ENST00000534013.5
    Conserved Domains (2) summary
    cd07074
    Location:92339
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cl02596
    Location:146
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RNA

  1. NR_073141.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
    Source sequence(s)
    AB085845, AP001533
  2. NR_073142.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
    Source sequence(s)
    AB085843, AP001533
  3. NR_073143.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) omits two coding exons, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
    Source sequence(s)
    AB085683, AP001533

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    101029624..101130681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718858.3XP_006718921.1  progesterone receptor isoform X1

    Related
    ENSP00000432352.1, ENST00000534780.5
    Conserved Domains (3) summary
    cd07172
    Location:563640
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1564
    Prog_receptor; Progesterone receptor
    cl11397
    Location:686786
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. XM_011542869.2XP_011541171.1  progesterone receptor isoform X2

    Conserved Domains (2) summary
    pfam02161
    Location:1564
    Prog_receptor; Progesterone receptor
    cl02596
    Location:563596
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
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