U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Septin11 septin 11 [ Mus musculus (house mouse) ]

Gene ID: 52398, updated on 8-Jan-2023

Summary

Official Symbol
Septin11provided by MGI
Official Full Name
septin 11provided by MGI
Primary source
MGI:MGI:1277214
See related
Ensembl:ENSMUSG00000058013 AllianceGenome:MGI:1277214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sept11; D5Ertd606e; 6230410I01Rik
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization; cytoskeleton-dependent cytokinesis; and regulation of synapse organization. Predicted to act upstream of or within cell division. Part of septin complex. Is expressed in cerebral cortex ventricular layer and otocyst. Orthologous to human SEPTIN11 (septin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 26.3), limb E14.5 (RPKM 19.8) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Septin11 in Genome Data Viewer
Location:
5 E2; 5 47.29 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (93227445..93329237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (93090995..93182368)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sosondowah ankyrin repeat domain family member B Neighboring gene predicted gene, 22915 Neighboring gene VISTA enhancer mm39 Neighboring gene cyclin I Neighboring gene RIKEN cDNA 2010109A12 gene Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization of symmetric synapse ISO
Inferred from Sequence Orthology
more info
 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of septin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009818.2NP_001009818.1  septin-11 isoform 3

    See identical proteins and their annotated locations for NP_001009818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC134827, BC064466, CO042161
    Consensus CDS
    CCDS51549.1
    UniProtKB/Swiss-Prot
    Q8C1B7
    UniProtKB/TrEMBL
    A0A6P5PLC2, A0A8C6HPM8
    Related
    ENSMUSP00000074293.8, ENSMUST00000074733.11
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  2. NM_001310669.1NP_001297598.1  septin-11 isoform 1

    See identical proteins and their annotated locations for NP_001297598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction in the 3' end compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is 1 aa shorter compared to isoform 4.
    Source sequence(s)
    AC134827, AK028475
    Consensus CDS
    CCDS80331.1
    UniProtKB/Swiss-Prot
    Q6P6I0, Q8C1B7
    UniProtKB/TrEMBL
    A0A6P7QZ09
    Related
    ENSMUSP00000143928.2, ENSMUST00000201421.4
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  3. NM_001310671.1NP_001297600.1  septin-11 isoform 2

    See identical proteins and their annotated locations for NP_001297600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site in the 3' coding region compared to variant 4. The resulting isoform (2) is shorter at the C-terminus compared to isoform 4.
    Source sequence(s)
    AC134827
    Consensus CDS
    CCDS80332.1
    UniProtKB/Swiss-Prot
    Q8C1B7
    UniProtKB/TrEMBL
    A0A6P5PXM3, A0A8C6HM35
    Related
    ENSMUSP00000144136.2, ENSMUST00000202308.4
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  4. NM_001347377.1NP_001334306.1  septin-11 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC134827
    Consensus CDS
    CCDS84906.1
    UniProtKB/TrEMBL
    A0A0J9YUL3, A0A6P7R2R4, A0A8C6HMX1
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    93227445..93329237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165288.1XP_036021181.1  septin-11 isoform X1

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  2. XM_036165289.1XP_036021182.1  septin-11 isoform X1

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  3. XM_006535098.5XP_006535161.1  septin-11 isoform X1

    See identical proteins and their annotated locations for XP_006535161.1

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  4. XM_006535099.5XP_006535162.1  septin-11 isoform X1

    See identical proteins and their annotated locations for XP_006535162.1

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  5. XM_006535100.5XP_006535163.1  septin-11 isoform X2

    See identical proteins and their annotated locations for XP_006535163.1

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  6. XM_006535101.5XP_006535164.1  septin-11 isoform X2

    See identical proteins and their annotated locations for XP_006535164.1

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  7. XM_006535103.5XP_006535166.1  septin-11 isoform X5

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  8. XM_011249531.4XP_011247833.1  septin-11 isoform X2

    See identical proteins and their annotated locations for XP_011247833.1

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  9. XM_017320978.3XP_017176467.1  septin-11 isoform X4

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  10. XM_011249532.4XP_011247834.1  septin-11 isoform X3

    Conserved Domains (1) summary
    cd01850
    Location:47315
    CDC_Septin; CDC/Septin GTPase family
  11. XM_017320982.1XP_017176471.1  septin-11 isoform X10

    Conserved Domains (1) summary
    cd01850
    Location:1249
    CDC_Septin; CDC/Septin GTPase family
  12. XM_017320980.3XP_017176469.1  septin-11 isoform X6

    UniProtKB/TrEMBL
    A0A0J9YUL3, A0A6P7R2R4, A0A8C6HMX1
    Related
    ENSMUSP00000144235.2, ENSMUST00000202217.3
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  13. XM_030254690.2XP_030110550.1  septin-11 isoform X7

    UniProtKB/Swiss-Prot
    Q6P6I0
    UniProtKB/TrEMBL
    A0A6P7QZ09
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  14. XM_017320981.3XP_017176470.1  septin-11 isoform X9

    UniProtKB/TrEMBL
    A0A6P7QX51, A0A8C6MZF8
    Related
    ENSMUSP00000143901.2, ENSMUST00000201700.4
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  15. XM_006535104.5XP_006535167.1  septin-11 isoform X6

    See identical proteins and their annotated locations for XP_006535167.1

    UniProtKB/TrEMBL
    A0A0J9YUL3, A0A6P7R2R4, A0A8C6HMX1
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  16. XM_036165291.1XP_036021184.1  septin-11 isoform X7

    UniProtKB/Swiss-Prot
    Q6P6I0
    UniProtKB/TrEMBL
    A0A6P7QZ09
    Conserved Domains (1) summary
    cd01850
    Location:38306
    CDC_Septin; CDC/Septin GTPase family
  17. XM_006535108.4XP_006535171.1  septin-11 isoform X10

    Conserved Domains (1) summary
    cd01850
    Location:1249
    CDC_Septin; CDC/Septin GTPase family
  18. XM_006535106.5XP_006535169.1  septin-11 isoform X8

    Conserved Domains (1) summary
    cd01850
    Location:36304
    CDC_Septin; CDC/Septin GTPase family
  19. XM_030254691.1XP_030110551.1  septin-11 isoform X11

    Conserved Domains (1) summary
    cd01850
    Location:1249
    CDC_Septin; CDC/Septin GTPase family
  20. XM_036165292.1XP_036021185.1  septin-11 isoform X11

    Conserved Domains (1) summary
    cd01850
    Location:1249
    CDC_Septin; CDC/Septin GTPase family

RNA

  1. XR_389284.5 RNA Sequence

  2. XR_001784719.3 RNA Sequence