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Klhl7 kelch-like 7 [ Mus musculus (house mouse) ]

Gene ID: 52323, updated on 26-Sep-2022

Summary

Official Symbol
Klhl7provided by MGI
Official Full Name
kelch-like 7provided by MGI
Primary source
MGI:MGI:1196453
See related
Ensembl:ENSMUSG00000028986 AllianceGenome:MGI:1196453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SBBI26; D5Ertd363e; 2700038B03Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in protein ubiquitination. Predicted to be located in several cellular components, including cytosol; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 3 and retinitis pigmentosa 42. Orthologous to human KLHL7 (kelch like family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.6), CNS E14 (RPKM 20.3) and 16 other tissues See more
Orthologs
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Genomic context

See Klhl7 in Genome Data Viewer
Location:
5 A3; 5 10.67 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24305563..24368363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24100565..24163369)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hyccin PI4KA lipid kinase complex subunit 1 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 18038 Neighboring gene gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 pseudogene Neighboring gene nucleoporin like 2 Neighboring gene heat shock protein 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kelch-like protein 7
Names
BTB/POZ domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161800.1NP_001155272.1  kelch-like protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001155272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC118010
    Consensus CDS
    CCDS51432.1
    UniProtKB/TrEMBL
    A0A8C6GCQ6, G3UW75
    Related
    ENSMUSP00000129461.2, ENSMUST00000163409.5
    Conserved Domains (6) summary
    smart00612
    Location:383430
    Kelch; Kelch domain
    smart00225
    Location:45140
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:326368
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:34138
    BTB; BTB/POZ domain
    pfam01344
    Location:420462
    Kelch_1; Kelch motif
    pfam07707
    Location:146248
    BACK; BTB And C-terminal Kelch
  2. NM_026448.3NP_080724.2  kelch-like protein 7 isoform 1

    See identical proteins and their annotated locations for NP_080724.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK083358, BB841624, BQ176920
    Consensus CDS
    CCDS19114.1
    UniProtKB/Swiss-Prot
    Q8BUL5, Q9CZP4
    UniProtKB/TrEMBL
    A0A6P5PLH1, A0A8C6GBR5
    Related
    ENSMUSP00000030841.6, ENSMUST00000030841.10
    Conserved Domains (5) summary
    PHA03098
    Location:37577
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:372416
    Kelch; KELCH repeat [structural motif]
    cd18237
    Location:23148
    BTB_POZ_KLHL7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7)
    cd18447
    Location:140237
    BACK_KLHL7; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7)
    pfam01344
    Location:371416
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24305563..24368363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535753.5XP_006535816.1  kelch-like protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A6P7R6E1
    Conserved Domains (4) summary
    PHA03098
    Location:5506
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:301345
    Kelch; KELCH repeat [structural motif]
    cd18447
    Location:69166
    BACK_KLHL7; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7)
    pfam01344
    Location:300345
    Kelch_1; Kelch motif

RNA

  1. XR_880834.4 RNA Sequence