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HBEGF heparin binding EGF like growth factor [ Bos taurus (domestic cattle) ]

Gene ID: 522921, updated on 30-Jan-2025
Official Symbol
HBEGFprovided by VGNC
Official Full Name
heparin binding EGF like growth factorprovided by VGNC
Primary source
VGNC:VGNC:29765
See related
BGD:BT23098; EnsemblRapid:ENSBTAG00070031167
Gene type
protein coding
RefSeq status
INFERRED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
DTR; HB-EGF
Orthologs
human mouse all
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See HBEGF in Genome Data Viewer
Location:
chromosome: 7
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (51532818..51545696, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene cysteine rich transmembrane module containing 1 Neighboring gene uncharacterized LOC132345757 Neighboring gene prefoldin subunit 1 Neighboring gene uncharacterized LOC107132639 Neighboring gene solute carrier family 4 member 9 Neighboring gene transfer RNA glutamic acid (anticodon CUC)

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Heparin-binding epidermal growth factor-like growth factor: a component in chromaffin granules which promotes the survival of nigrostriatal dopaminergic neurones in vitro and in vivo. Hanke M, et al. Neuroscience, 2004. PMID 15026116
  2. Expression of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Bovine Endometrium: Effects of HB-EGF and Interferon-τ on Prostaglandin Production. Takatsu K, et al. Reprod Domest Anim, 2015 Jun. PMID 25779761
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.
    Title: Expression of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Bovine Endometrium: Effects of HB-EGF and Interferon-τ on Prostaglandin Production.
  2. Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease.
    Title: Heparin-binding epidermal growth factor-like growth factor: a component in chromaffin granules which promotes the survival of nigrostriatal dopaminergic neurones in vitro and in vivo.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
proheparin-binding EGF-like growth factor
Names
diphtheria toxin receptor
heparin-binding epidermal growth factor-like growth factor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144090.1 → NP_001137562.1  proheparin-binding EGF-like growth factor precursor

    See identical proteins and their annotated locations for NP_001137562.1

    Status: INFERRED

    Source sequence(s)
    NKLS02000007
    UniProtKB/TrEMBL
    E1BIN8
    Related
    ENSBTAP00070043001.1, ENSBTAT00070070567.1
    Conserved Domains (1) summary
    cl28647
    Location:108 → 148
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    51532818..51545696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888201.1 → XP_059744184.1  proheparin-binding EGF-like growth factor isoform X2

    UniProtKB/TrEMBL
    E1BIN8

  2. XM_059888200.1 → XP_059744183.1  proheparin-binding EGF-like growth factor isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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