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PGF placental growth factor [ Homo sapiens (human) ]

Gene ID: 5228, updated on 9-Oct-2022

Summary

Official Symbol
PGFprovided by HGNC
Official Full Name
placental growth factorprovided by HGNC
Primary source
HGNC:HGNC:8893
See related
Ensembl:ENSG00000119630 MIM:601121; AllianceGenome:HGNC:8893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGFL; PIGF; PLGF; PlGF-2; D12S1900; SHGC-10760
Summary
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Annotation information
Note: PGF (Gene ID: 5228) and PIGF (Gene ID: 5281) share the PIGF symbol/alias in common. PIGF is a widely used alternative gene symbol for placental growth factor (PGF), which can be confused with the official symbol for phosphatidylinositol glycan anchor biosynthesis class F (PIGF). [06 Jul 2018]
Expression
Biased expression in placenta (RPKM 36.3), thyroid (RPKM 24.1) and 13 other tissues See more
Orthologs
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Genomic context

See PGF in Genome Data Viewer
Location:
14q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74941830..74955764, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69150944..69164879, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75408533..75422467, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 140 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene ribosomal protein S6 kinase like 1 Neighboring gene uncharacterized LOC107984690 Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene RNA, U6 small nuclear 689, pseudogene Neighboring gene mutL homolog 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in induction of positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mast cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
placenta growth factor
Names
placental growth factor, vascular endothelial growth factor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029168.1 RefSeqGene

    Range
    5168..18931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207012.1NP_001193941.1  placenta growth factor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region relative to variant 1. It encodes the shortest isoform (2, also known as PlGF-1 or PLGF-1), which lacks a 21 amino acid heparin binding domain found in variant 1 (PMID:8148155).
    Source sequence(s)
    AC006530, BX248289, BX356823, X54936
    Consensus CDS
    CCDS55932.1
    UniProtKB/Swiss-Prot
    P49763
    UniProtKB/TrEMBL
    Q86TW6
    Related
    ENSP00000451413.1, ENST00000553716.5
    Conserved Domains (2) summary
    PHA02661
    Location:4134
    PHA02661; vascular endothelial growth factor like protein; Provisional
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  2. NM_001293643.1NP_001280572.1  placenta growth factor isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (3) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AC006530, AL543693, BX248289
    Consensus CDS
    CCDS73664.1
    UniProtKB/TrEMBL
    G3XA84, Q86TW6
    Related
    ENSP00000238607.6, ENST00000238607.10
    Conserved Domains (2) summary
    PHA02661
    Location:4133
    PHA02661; vascular endothelial growth factor like protein; Provisional
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  3. NM_002632.6NP_002623.2  placenta growth factor isoform 1 precursor

    See identical proteins and their annotated locations for NP_002623.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as PlGF-2, PLGF-2 or PGF-2) and contains a 21 amino acid region that is thought to bind heparin (PMID:8148155).
    Source sequence(s)
    AC006530
    Consensus CDS
    CCDS9835.1
    UniProtKB/Swiss-Prot
    P49763
    UniProtKB/TrEMBL
    Q53XY6, Q86TW6
    Related
    ENSP00000451040.1, ENST00000555567.6
    Conserved Domains (2) summary
    PHA02661
    Location:4134
    PHA02661; vascular endothelial growth factor like protein; Provisional
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74941830..74955764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431476.1XP_047287432.1  placenta growth factor isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    69150944..69164879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)