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ITK IL2 inducible T cell kinase [ Bos taurus (domestic cattle) ]

Gene ID: 522311, updated on 5-Sep-2025
Official Symbol
ITKprovided by VGNC
Official Full Name
IL2 inducible T cell kinaseprovided by VGNC
Primary source
VGNC:VGNC:30338
See related
BGD:BT12417; EnsemblRapid:ENSBTAG00070004367
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See ITK in Genome Data Viewer
Location:
chromosome: 7
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (68871861..68934055)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 7 Neighboring gene uncharacterized LOC132345782 Neighboring gene golgi associated RAB2B interactor family member 3 Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene fibronectin type III domain containing 9 Neighboring gene NIPA like domain containing 4

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A positional candidate gene association analysis of susceptibility to paratuberculosis on bovine chromosome 7. Sallam AM, et al. Infect Genet Evol, 2018 Nov. PMID 30056168
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ITK single nucleotide polymorphism association with predisposition to paratuberculosis in Holstein cows.
    Title: A positional candidate gene association analysis of susceptibility to paratuberculosis on bovine chromosome 7.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC165932

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in NK T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase ITK/TSK
NP_001098858.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105388.1 → NP_001098858.1  tyrosine-protein kinase ITK/TSK

    See identical proteins and their annotated locations for NP_001098858.1

    Status: PROVISIONAL

    Source sequence(s)
    BC153237
    UniProtKB/TrEMBL
    A0A3Q1LNN2, A7Z039
    Related
    ENSBTAP00070005719.1, ENSBTAT00070009929.1
    Conserved Domains (4) summary
    cd05112
    Location:358 → 613
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:232 → 340
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:174 → 229
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    68871861..68934055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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