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CRHR2 corticotropin releasing hormone receptor 2 [ Bos taurus (domestic cattle) ]

Gene ID: 521831, updated on 30-Jan-2025
Official Symbol
CRHR2provided by VGNC
Official Full Name
corticotropin releasing hormone receptor 2provided by VGNC
Primary source
VGNC:VGNC:27709
See related
EnsemblRapid:ENSBTAG00070027602
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See CRHR2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (65647884..65692602)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein-related protein 9-like Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene indolethylamine N-methyltransferase Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC132345106

Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland. Squillacioti C, et al. Gen Comp Endocrinol, 2011 Jul 1. PMID 21504748
  2. Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland. Squillacioti C, et al. Anat Histol Embryol, 2014 Dec. PMID 24219151
  3. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
    Title: Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland.
  2. CRHR1 and CRHR2 are expressed in the bovine adrenal gland.
    Title: Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables corticotrophin-releasing factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables corticotropin-releasing hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
corticotropin-releasing factor receptor 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192545.1 → NP_001179474.1  corticotropin-releasing factor receptor 2

    See identical proteins and their annotated locations for NP_001179474.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000004
    UniProtKB/TrEMBL
    A0A3Q1N5S8
    Related
    ENSBTAP00070037636.1, ENSBTAT00070062821.1
    Conserved Domains (2) summary
    smart00008
    Location:36 → 107
    HormR; Domain present in hormone receptors
    pfam00002
    Location:113 → 355
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    65647884..65692602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005205492.5 → XP_005205549.1  corticotropin-releasing factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M141
    Related
    ENSBTAP00070037651.1, ENSBTAT00070062840.1
    Conserved Domains (2) summary
    smart00008
    Location:61 → 132
    HormR; Domain present in hormone receptors
    pfam00002
    Location:138 → 380
    7tm_2; 7 transmembrane receptor (Secretin family)
Nucleotide Protein Strain
Heading Accession and Version

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