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RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Bos taurus (cattle) ]

Gene ID: 521196, updated on 20-Dec-2022

Summary

Gene symbol
RAF1
Gene description
Raf-1 proto-oncogene, serine/threonine kinase
See related
Ensembl:ENSBTAG00000045748
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
C-RAF
Orthologs
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Genomic context

See RAF1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 22 NC_037349.1 (56467459..56543344)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 22 AC_000179.1 (57122371..57204961)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104975605 Neighboring gene transmembrane protein 40 Neighboring gene makorin ring finger protein 2 Neighboring gene PPARG-TSEN2 Neighboring gene MKRN2 opposite strand Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene tRNA splicing endonuclease subunit 2

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC165882

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in death-inducing signaling complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in face development IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to muscle stretch IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
proto-oncogene c-RAF
NP_001095975.1
XP_024838494.1
XP_024838495.1
XP_024838496.1
XP_024838497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102505.1NP_001095975.1  RAF proto-oncogene serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001095975.1

    Status: PROVISIONAL

    Source sequence(s)
    BC151319
    UniProtKB/Swiss-Prot
    A7E3S4
    UniProtKB/TrEMBL
    A0A4W2BS84, A0A8B9YFY9, L8I7L6
    Related
    ENSBTAP00000005930.6, ENSBTAT00000005930.6
    Conserved Domains (3) summary
    cd01816
    Location:57131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:356638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    56467459..56543344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024982726.1XP_024838494.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A4W2BS84, A0A8B9YFY9, L8I7L6
    Conserved Domains (3) summary
    cd01816
    Location:57131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:356638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. XM_024982727.1XP_024838495.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    A7YY51
    UniProtKB/TrEMBL
    A0A4W2IB76
    Conserved Domains (3) summary
    cd01816
    Location:57131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:336618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  3. XM_024982728.1XP_024838496.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    A7YY51
    UniProtKB/TrEMBL
    A0A4W2IB76
    Related
    ENSBTAP00000060802.1, ENSBTAT00000081792.1
    Conserved Domains (3) summary
    cd01816
    Location:57131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:336618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  4. XM_024982729.1XP_024838497.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    A7YY51
    UniProtKB/TrEMBL
    A0A4W2IB76
    Related
    ENSBTAP00000048678.3, ENSBTAT00000054270.3
    Conserved Domains (3) summary
    cd01816
    Location:57131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:336618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:139187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)