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Pvr poliovirus receptor [ Mus musculus (house mouse) ]

Gene ID: 52118, updated on 12-Feb-2023

Summary

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Official Symbol
Pvrprovided by MGI
Official Full Name
poliovirus receptorprovided by MGI
Primary source
MGI:MGI:107741
See related
Ensembl:ENSMUSG00000040511 AllianceGenome:MGI:107741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PVS; mE4; HVED; Taa1; CD155; Tage4; necl-5; D7Ertd458e; 3830421F03Rik
Summary
Enables dynein light chain binding activity. Acts upstream of or within cell migration and cell-cell adhesion. Located in cell surface and plasma membrane. Orthologous to human PVR (PVR cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 14.4), placenta adult (RPKM 14.0) and 28 other tissues See more
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Genomic context

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See Pvr in Genome Data Viewer
Location:
7 A3; 7 9.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19637503..19655068, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19903578..19921143, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 16 Neighboring gene predicted gene, 19345 Neighboring gene CEA cell adhesion molecule 19 Neighboring gene ribosomal protein L14 pseudogene Neighboring gene predicted gene 16251 Neighboring gene immunoglobulin superfamily, member 23 Neighboring gene ribosomal protein L7A, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Necl-5/PVR enhances PDGF-induced attraction of growing microtubules to the plasma membrane of the leading edge of moving NIH3T3 cells. Minami A, et al. Genes Cells, 2010 Nov. PMID 20964795
  2. CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus. Qiu Q, et al. J Immunol, 2010 Feb 15. PMID 20048123
  3. Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate. Abe A, et al. J Pathol, 2009 Jan. PMID 18973187
  4. Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lungs. Morimoto K, et al. Oncogene, 2008 Jan 10. PMID 17637752
  5. The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens. Maier MK, et al. Eur J Immunol, 2007 Aug. PMID 17621371

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.
    Title: T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.
  2. Results indicate that TIGIT enhanced on tolerant T cells may function as a ligand of its paired receptor CD155 to transduce signaling into its expressing naive T cells to accelerate new TIGIT expressions as well as IL-2 suppression via B lymphocyte-induced maturation protein 1 enhancement.
    Title: CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity.
  3. The hybrid complex structure of CD226-ecto binding to the first domain of CD155 (hCD155-D1) reveals a conserved binding interface with the first domain of CD226 (D1), whereas the second domain of CD226 (D2) both provides structural supports for the unique architecture of CD226 and forms direct interactions with CD155.
    Title: Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
  4. Data show that CD155 protein/CD226 antigen mainly mediates the interaction between NK cells and leukemic cells in acute myeloid leukemia. To investigate the interaction between leukemic cells
    Title: NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions.
  5. absence of either CD155 or CD226 in BALB/c mice causes a profound shift in the Natural Killer T-Cells subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells.
    Title: CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation.
  6. Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors.
    Title: Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice.
  7. CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
    Title: CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
  8. Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis
    Title: CEACAM2-L on spermatids interacts with poliovirus receptor on Sertoli cells in mouse seminiferous epithelium.
  9. TIGIT/PVR ligation signaling mediates suppression of IFN-gamma production via the NF-kappaB pathway.
    Title: T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling.
  10. Our data suggest that CD155 regulates T(h)2 differentiation
    Title: Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein light chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
  
involved_in susceptibility to T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in susceptibility to natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
poliovirus receptor
Names
tumor-associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027514.2 → NP_081790.1  poliovirus receptor precursor

    See identical proteins and their annotated locations for NP_081790.1

    Status: VALIDATED

    Source sequence(s)
    BC032283, BY276828
    Consensus CDS
    CCDS20916.1
    UniProtKB/TrEMBL
    Q8K094
    Related
    ENSMUSP00000039205.8, ENSMUST00000043517.8
    Conserved Domains (3) summary
    cd05718
    Location:44 → 142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145 → 240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:35 → 141
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19637503..19655068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009310.1: Suppressed sequence

    Description
    NM_009310.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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