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Pvr poliovirus receptor [ Mus musculus (house mouse) ]

Gene ID: 52118, updated on 12-May-2024

Summary

Official Symbol
Pvrprovided by MGI
Official Full Name
poliovirus receptorprovided by MGI
Primary source
MGI:MGI:107741
See related
Ensembl:ENSMUSG00000040511 AllianceGenome:MGI:107741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PVS; mE4; HVED; Taa1; CD155; Tage4; necl-5; D7Ertd458e; 3830421F03Rik
Summary
Enables dynein light chain binding activity. Acts upstream of or within cell migration and cell-cell adhesion. Located in cell surface and plasma membrane. Orthologous to human PVR (PVR cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 14.4), placenta adult (RPKM 14.0) and 28 other tissues See more
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Genomic context

See Pvr in Genome Data Viewer
Location:
7 A3; 7 9.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19637503..19655068, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19903578..19921143, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 16 Neighboring gene predicted gene, 19345 Neighboring gene STARR-positive B cell enhancer ABC_E11343 Neighboring gene STARR-seq mESC enhancer starr_18229 Neighboring gene CEA cell adhesion molecule 19 Neighboring gene ribosomal protein L14 pseudogene Neighboring gene predicted gene 16251 Neighboring gene STARR-seq mESC enhancer starr_18231 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20517919-20518126 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20518638-20518747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20520941-20521094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20525341-20525450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20525675-20525828 Neighboring gene immunoglobulin superfamily, member 23 Neighboring gene ribosomal protein L7A, pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein light chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poliovirus receptor
Names
tumor-associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027514.2NP_081790.1  poliovirus receptor precursor

    See identical proteins and their annotated locations for NP_081790.1

    Status: VALIDATED

    Source sequence(s)
    BC032283, BY276828
    Consensus CDS
    CCDS20916.1
    UniProtKB/TrEMBL
    Q8BVF6, Q8K094, Q91WP1
    Related
    ENSMUSP00000039205.8, ENSMUST00000043517.8
    Conserved Domains (3) summary
    cd05718
    Location:44142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:35141
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19637503..19655068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009310.1: Suppressed sequence

    Description
    NM_009310.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.