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Tmem38b transmembrane protein 38B [ Mus musculus (house mouse) ]

Gene ID: 52076, updated on 12-May-2024

Summary

Official Symbol
Tmem38bprovided by MGI
Official Full Name
transmembrane protein 38Bprovided by MGI
Primary source
MGI:MGI:1098718
See related
Ensembl:ENSMUSG00000028420 AllianceGenome:MGI:1098718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mg33b; TRIC-B; D4Ertd89e; 1600017F22Rik
Summary
Predicted to enable potassium channel activity. Acts upstream of or within several processes, including cellular response to caffeine; lung development; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.5), liver adult (RPKM 7.2) and 26 other tissues See more
Orthologs
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Genomic context

See Tmem38b in Genome Data Viewer
Location:
4 B2; 4 28.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (53825988..53862019)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (53825988..53862019)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10245 Neighboring gene ribosomal protein S15A, pseudogene 8 Neighboring gene T cell acute lymphocytic leukemia 2 Neighboring gene STARR-seq mESC enhancer starr_10246 Neighboring gene STARR-seq mESC enhancer starr_10248 Neighboring gene STARR-seq mESC enhancer starr_10250 Neighboring gene nuclear encoded rRNA 5S 185 Neighboring gene predicted gene 12468 Neighboring gene predicted gene, 54229 Neighboring gene predicted gene, 23745

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to caffeine IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within secretion by lung epithelial cell involved in lung growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trimeric intracellular cation channel type B
Names
Mitsugumin33B
TRICB
mitsugumin-33B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028053.2NP_082329.1  trimeric intracellular cation channel type B

    See identical proteins and their annotated locations for NP_082329.1

    Status: VALIDATED

    Source sequence(s)
    AK005479, AK136131, AK150377, BY138283
    Consensus CDS
    CCDS18193.1
    UniProtKB/Swiss-Prot
    A2AQG4, Q3U6M4, Q3UBM6, Q3UWS8, Q9DAV9
    Related
    ENSMUSP00000030127.7, ENSMUST00000030127.13
    Conserved Domains (1) summary
    pfam05197
    Location:39222
    TRIC; TRIC channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    53825988..53862019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538083.2XP_006538146.1  trimeric intracellular cation channel type B isoform X1

    Conserved Domains (1) summary
    pfam05197
    Location:1106
    TRIC; TRIC channel