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Rab11fip5 RAB11 family interacting protein 5 (class I) [ Mus musculus (house mouse) ]

Gene ID: 52055, updated on 12-May-2024

Summary

Official Symbol
Rab11fip5provided by MGI
Official Full Name
RAB11 family interacting protein 5 (class I)provided by MGI
Primary source
MGI:MGI:1098586
See related
Ensembl:ENSMUSG00000051343 AllianceGenome:MGI:1098586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAF1; RIP11; D6Ertd32e; 9130206P09Rik
Summary
Predicted to enable gamma-tubulin binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus and regulated exocytosis. Acts upstream of or within cellular response to interferon-gamma. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human RAB11FIP5 (RAB11 family interacting protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 59.8), ovary adult (RPKM 19.7) and 20 other tissues See more
Orthologs
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Genomic context

See Rab11fip5 in Genome Data Viewer
Location:
6 C3; 6 37.35 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85311944..85351663, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85334962..85374684, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene empty spiracles homeobox 1 Neighboring gene sideroflexin 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:85187210-85187411 Neighboring gene STARR-seq mESC enhancer starr_16498 Neighboring gene STARR-positive B cell enhancer ABC_E4838 Neighboring gene STARR-positive B cell enhancer ABC_E10387 Neighboring gene microRNA 705 Neighboring gene RIKEN cDNA 4933423K11 gene Neighboring gene notochord homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0857

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rab11 family-interacting protein 5
Names
rab11-FIP5
rab11-interacting protein Rip11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003955.2NP_001003955.1  rab11 family-interacting protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001003955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK129230, BC044833
    Consensus CDS
    CCDS85083.1
    UniProtKB/TrEMBL
    A0A0N4SW73, Q6ZQ33
    Related
    ENSMUSP00000145402.2, ENSMUST00000204087.2
    Conserved Domains (2) summary
    pfam09457
    Location:12661312
    RBD-FIP; FIP domain
    cl14603
    Location:21167
    C2; C2 domain
  2. NM_177466.4NP_803417.3  rab11 family-interacting protein 5 isoform 2

    See identical proteins and their annotated locations for NP_803417.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK129230, BC044833
    Consensus CDS
    CCDS20292.1
    UniProtKB/Swiss-Prot
    C4IXU4, Q8R361
    Related
    ENSMUSP00000058305.8, ENSMUST00000060837.10
    Conserved Domains (2) summary
    pfam09457
    Location:593639
    RBD-FIP; FIP domain
    cl14603
    Location:21167
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85311944..85351663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506366.3XP_006506429.1  rab11 family-interacting protein 5 isoform X1

    UniProtKB/TrEMBL
    Q6ZQ33
    Conserved Domains (2) summary
    pfam09457
    Location:11661212
    RBD-FIP; FIP domain
    cl14603
    Location:21167
    C2; C2 domain