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Pbk PDZ binding kinase [ Mus musculus (house mouse) ]

Gene ID: 52033, updated on 21-Apr-2024

Summary

Official Symbol
Pbkprovided by MGI
Official Full Name
PDZ binding kinaseprovided by MGI
Primary source
MGI:MGI:1289156
See related
Ensembl:ENSMUSG00000022033 AllianceGenome:MGI:1289156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TOPK; D14Ertd732e; 2810434B10Rik
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to UV; negative regulation of cellular protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 25.9), liver E14 (RPKM 15.6) and 10 other tissues See more
Orthologs
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Genomic context

Location:
14 D1; 14 34.36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66043337..66055271)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65805911..65817822)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53863 Neighboring gene scavenger receptor class A, member 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66424601-66424784 Neighboring gene STARR-seq mESC enhancer starr_36982 Neighboring gene STARR-seq mESC enhancer starr_36983 Neighboring gene STARR-positive B cell enhancer ABC_E5449 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene coiled-coil domain containing 25

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lymphokine-activated killer T-cell-originated protein kinase
Names
MAPKK-like protein kinase
T-LAK cell-originated protein kinase
NP_001404430.1
NP_075698.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417501.1NP_001404430.1  lymphokine-activated killer T-cell-originated protein kinase

    Status: VALIDATED

    Source sequence(s)
    AC125058
    UniProtKB/Swiss-Prot
    Q922V2, Q9D184, Q9JJ78
  2. NM_023209.3NP_075698.1  lymphokine-activated killer T-cell-originated protein kinase

    See identical proteins and their annotated locations for NP_075698.1

    Status: VALIDATED

    Source sequence(s)
    AC125058
    Consensus CDS
    CCDS27215.1
    UniProtKB/Swiss-Prot
    Q922V2, Q9D184, Q9JJ78
    Related
    ENSMUSP00000022612.4, ENSMUST00000022612.10
    Conserved Domains (1) summary
    cd14001
    Location:31318
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66043337..66055271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)