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Pibf1 progesterone immunomodulatory binding factor 1 [ Mus musculus (house mouse) ]

Gene ID: 52023, updated on 7-Aug-2026
Official Symbol
Pibf1provided by MGI
Official Full Name
progesterone immunomodulatory binding factor 1provided by MGI
Primary source
MGI:MGI:1261910
See related
Ensembl:ENSMUSG00000022064 AllianceGenome:MGI:1261910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable interleukin-4 receptor binding activity. Predicted to be involved in several processes, including mitotic sister chromatid segregation; regulation of biosynthetic process; and regulation of protein phosphorylation. Predicted to be located in centriolar satellite; extracellular space; and nucleus. Predicted to be active in microtubule organizing center. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in Joubert syndrome 33. Orthologous to human PIBF1 (progesterone immunomodulatory binding factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.5), ovary adult (RPKM 3.7) and 28 other tissues See more
Orthologs
all
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See Pibf1 in Genome Data Viewer
Location:
14 E2.2; 14 49.27 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99336892..99492335)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99099424..99254899)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene bora, aurora kinase A activator Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene STARR-seq mESC enhancer starr_37436 Neighboring gene Kruppel-like transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_37437 Neighboring gene predicted gene, 22984

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance. Szekeres-Bartho J, et al. J Reprod Immunol, 1996 Aug. PMID 8887124
  2. Altered Immune Response and Implantation Failure in Progesterone-Induced Blocking Factor-Deficient Mice. Csabai T, et al. Front Immunol, 2020. PMID 32218780, Free PMC Article
  3. The involvement of the progesterone receptor in PIBF and Gal-1 expression in the mouse endometrium. Mulac-Jeričević B, et al. Am J Reprod Immunol, 2019 May. PMID 30803068
  4. The antiabortive effect of progesterone-induced blocking factor in mice is manifested by modulating NK activity. Szekeres-Bartho J, et al. Cell Immunol, 1997 May 1. PMID 9178647
  5. Progesterone and non-specific immunologic mechanisms in pregnancy. Szekeres-Bartho J, et al. Am J Reprod Immunol, 1997 Sep. PMID 9325489

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
    Title: PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
  2. Data suggest, that PIBF transported by the extracellular vesicles( EVs) from the embryo to maternal lymphocytes might induce increased IL-10 production by the latter, this way contributing to the Th2 dominant immune responses described during pregnancy.
    Title: PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells.
  3. B cell deficiency in mice resulted in a lower uterine level of active progesterone-induced blocking factor 1 (PIBF1), and susceptibility to preterm labor after inflammation. B cells are a significant producer of PIBF1 in mouse uterus in late gestation.
    Title: Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Clone Names

  • 1700017E21Rik, 4930513H15Rik, 4933438D16Rik, 4933439E17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-4 receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of natural killer cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
progesterone-induced-blocking factor 1
Names
progesterone-induced blocking factor 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029320.4 → NP_083596.2  progesterone-induced-blocking factor 1

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154
    Consensus CDS
    CCDS36997.1
    UniProtKB/TrEMBL
    E9Q6K3
    Related
    ENSMUSP00000022650.8, ENSMUST00000022650.10
    Conserved Domains (1) summary
    pfam01496
    Location:475 → 558
    V_ATPase_I; V-type ATPase 116kDa subunit family

RNA

  1. NR_188872.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154
    Related
    ENSMUST00000525166.1

  2. NR_188873.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154
    Related
    ENSMUST00000525170.1

  3. NR_188874.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    99336892..99492335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519256.5 → XP_006519319.1  progesterone-induced-blocking factor 1 isoform X5

    UniProtKB/TrEMBL
    Q8BIR5
    Related
    ENSMUSP00000303531.1, ENSMUST00000525168.1
    Conserved Domains (1) summary
    TIGR02168
    Location:125 → 406
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006519253.5 → XP_006519316.1  progesterone-induced-blocking factor 1 isoform X3

    Related
    ENSMUSP00000303525.1, ENSMUST00000525162.1
    Conserved Domains (2) summary
    TIGR02168
    Location:234 → 572
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:44 → 355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. XM_036158751.1 → XP_036014644.1  progesterone-induced-blocking factor 1 isoform X1

    Related
    ENSMUSP00000354356.1, ENSMUST00000575993.1
    Conserved Domains (2) summary
    COG1196
    Location:21 → 684
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:234 → 538
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_003950865.2 RNA Sequence

    Related
    ENSMUST00000525172.1

  2. XR_383193.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029454.4: Suppressed sequence

    Description
    NM_029454.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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