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PFDN2 prefoldin subunit 2 [ Homo sapiens (human) ]

Gene ID: 5202, updated on 11-Jun-2025
Official Symbol
PFDN2provided by HGNC
Official Full Name
prefoldin subunit 2provided by HGNC
Primary source
HGNC:HGNC:8867
See related
Ensembl:ENSG00000143256 MIM:613466; AllianceGenome:HGNC:8867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFD2
Summary
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 33.7), brain (RPKM 30.3) and 25 other tissues See more
Orthologs
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See PFDN2 in Genome Data Viewer
Location:
1q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161100561..161118037, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160238042..160255506, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161070351..161087827, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 4 Neighboring gene NECTIN4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1467 Neighboring gene kelch domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161087283-161088263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161093620-161094120 Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161101327-161102150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1977 Neighboring gene linc-UFC1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein folding chaperone IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of amyloid fibril formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein stabilization NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of prefoldin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
 
part_of prefoldin complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein folding chaperone complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
prefoldin subunit 2
Names
prefoldin 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012394.4NP_036526.2  prefoldin subunit 2

    Status: REVIEWED

    Source sequence(s)
    AF165883, BC012464
    Consensus CDS
    CCDS1217.1
    UniProtKB/Swiss-Prot
    Q9P0P7, Q9UHV9, Q9UN05
    UniProtKB/TrEMBL
    B1AQP2
    Related
    ENSP00000356989.3, ENST00000368010.4
    Conserved Domains (1) summary
    pfam01920
    Location:27128
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161100561..161118037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509624.4XP_011507926.1  prefoldin subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UHV9
    Conserved Domains (1) summary
    pfam01920
    Location:180
    Prefoldin_2; Prefoldin subunit

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160238042..160255506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337022.1XP_054192997.1  prefoldin subunit 2 isoform X1