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PFDN2 prefoldin subunit 2 [ Homo sapiens (human) ]

Gene ID: 5202, updated on 10-Oct-2020

Summary

Official Symbol
PFDN2provided by HGNC
Official Full Name
prefoldin subunit 2provided by HGNC
Primary source
HGNC:HGNC:8867
See related
Ensembl:ENSG00000143256 MIM:613466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFD2
Summary
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 33.7), brain (RPKM 30.3) and 25 other tissues See more
Orthologs

Genomic context

See PFDN2 in Genome Data Viewer
Location:
1q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161100556..161118043, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161070346..161087866, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 4 Neighboring gene NECTIN4 antisense RNA 1 Neighboring gene kelch domain containing 9 Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene linc-UFC1 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding involved in protein folding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
prefoldin complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
prefoldin subunit 2
Names
prefoldin 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012394.4NP_036526.2  prefoldin subunit 2

    See identical proteins and their annotated locations for NP_036526.2

    Status: REVIEWED

    Source sequence(s)
    AF165883, BC012464
    Consensus CDS
    CCDS1217.1
    UniProtKB/Swiss-Prot
    Q9UHV9
    UniProtKB/TrEMBL
    B1AQP2
    Related
    ENSP00000356989.3, ENST00000368010.4
    Conserved Domains (1) summary
    pfam01920
    Location:24126
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161100556..161118043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509624.3XP_011507926.1  prefoldin subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011507926.1

    UniProtKB/Swiss-Prot
    Q9UHV9
    Conserved Domains (1) summary
    pfam01920
    Location:179
    Prefoldin_2; Prefoldin subunit
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