LGR5 leucine rich repeat containing G protein-coupled receptor 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LGR5provided by VGNC
Official Full Name: leucine rich repeat containing G protein-coupled receptor 5provided by VGNC
Primary source: VGNC:VGNC:30862
See related: BGD:BT16121; EnsemblRapid:ENSBTAG00070025058
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (1094495..1219729)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001192520.3 → NP_001179449.3 leucine-rich repeat-containing G-protein coupled receptor 5 precursor

Status: PROVISIONAL

Source sequence(s)

NKLS02000005

UniProtKB/TrEMBL

A0A452DIK6, A0AAA9SBC5

Related

ENSBTAP00070033912.1, ENSBTAT00070056726.1

Conserved Domains (5) summary

smart00013
Location:33 → 70

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:354 → 375

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:68 → 91

LRR_RI; leucine-rich repeat [structural motif]

cd15363
Location:558 → 831

7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

cl26793
Location:71 → 452

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional