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Kctd18 potassium channel tetramerisation domain containing 18 [ Mus musculus (house mouse) ]

Gene ID: 51960, updated on 26-Sep-2022

Summary

Official Symbol
Kctd18provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 18provided by MGI
Primary source
MGI:MGI:3603813
See related
Ensembl:ENSMUSG00000054770 AllianceGenome:MGI:3603813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932411A20Rik; 6530404F10Rik
Summary
Is expressed in central nervous system and retina. Orthologous to human KCTD18 (potassium channel tetramerization domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E14 (RPKM 3.8) and 27 other tissues See more
Orthologs
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Genomic context

See Kctd18 in Genome Data Viewer
Location:
1; 1 C1.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (57994260..58009298, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57955101..57970141, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene small nucleolar RNA U13 Neighboring gene shugoshin 2A Neighboring gene aldehyde oxidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing protein KCTD18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159864.1NP_001153336.1  BTB/POZ domain-containing protein KCTD18 isoform 1

    See identical proteins and their annotated locations for NP_001153336.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC110735, AK132699, BB678909, BY080515, BY736102
    Consensus CDS
    CCDS48269.1
    UniProtKB/TrEMBL
    E0CZ26
    Related
    ENSMUSP00000110052.4, ENSMUST00000114410.10
    Conserved Domains (2) summary
    cd18372
    Location:23123
    BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
    pfam17669
    Location:339414
    DUF5529; Family of unknown function (DUF5529)
  2. NM_001159865.1NP_001153337.1  BTB/POZ domain-containing protein KCTD18 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BB678909, BC075692, BY080515, CA530605
    Consensus CDS
    CCDS48268.1
    UniProtKB/TrEMBL
    E9Q945, Q6DI85
    Related
    ENSMUSP00000130952.2, ENSMUST00000164963.8
    Conserved Domains (1) summary
    cl38908
    Location:23107
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RNA

  1. NR_027630.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' end and at the 3' end of an internal exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be a noncoding transcript.
    Source sequence(s)
    BB678909, BC075692
    Related
    ENSMUST00000161608.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    57994260..58009298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496136.5XP_006496199.1  BTB/POZ domain-containing protein KCTD18 isoform X1

    See identical proteins and their annotated locations for XP_006496199.1

    UniProtKB/TrEMBL
    E0CZ26
    Conserved Domains (2) summary
    cd18372
    Location:23123
    BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
    pfam17669
    Location:339414
    DUF5529; Family of unknown function (DUF5529)
  2. XM_036152324.1XP_036008217.1  BTB/POZ domain-containing protein KCTD18 isoform X3

    UniProtKB/TrEMBL
    E9Q945
    Conserved Domains (1) summary
    cl38908
    Location:23107
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  3. XM_006496135.4XP_006496198.1  BTB/POZ domain-containing protein KCTD18 isoform X1

    See identical proteins and their annotated locations for XP_006496198.1

    UniProtKB/TrEMBL
    E0CZ26
    Conserved Domains (2) summary
    cd18372
    Location:23123
    BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
    pfam17669
    Location:339414
    DUF5529; Family of unknown function (DUF5529)
  4. XM_017321677.3XP_017177166.1  BTB/POZ domain-containing protein KCTD18 isoform X4

  5. XM_017321676.3XP_017177165.1  BTB/POZ domain-containing protein KCTD18 isoform X2

    Conserved Domains (1) summary
    pfam17669
    Location:218293
    DUF5529; Family of unknown function (DUF5529)
  6. XM_036152329.1XP_036008222.1  BTB/POZ domain-containing protein KCTD18 isoform X4

    Conserved Domains (1) summary
    pfam15323
    Location:66174
    Ashwin; Developmental protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030211.3: Suppressed sequence

    Description
    NM_030211.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.