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Fubp1 far upstream element (FUSE) binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 51886, updated on 3-Apr-2024

Summary

Official Symbol
Fubp1provided by MGI
Official Full Name
far upstream element (FUSE) binding protein 1provided by MGI
Primary source
MGI:MGI:1196294
See related
Ensembl:ENSMUSG00000028034 AllianceGenome:MGI:1196294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP; Fubp; Fubp4; D3Ertd330e; 9530027K12Rik
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including developmental cell growth; hematopoietic stem cell proliferation; and somatic stem cell division. Located in synapse. Is expressed in several structures, including central nervous system; gonad; limb; sensory organ; and spleen. Orthologous to human FUBP1 (far upstream element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 43.8), CNS E14 (RPKM 43.1) and 27 other tissues See more
Orthologs
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Genomic context

See Fubp1 in Genome Data Viewer
Location:
3 H3; 3 77.05 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151916059..151942467)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152210422..152236830)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31881 Neighboring gene GIPC PDZ domain containing family, member 2 Neighboring gene predicted gene, 40179 Neighboring gene STARR-seq mESC enhancer starr_09281 Neighboring gene STARR-seq mESC enhancer starr_09282 Neighboring gene STARR-seq mESC enhancer starr_09283 Neighboring gene DnaJ heat shock protein family (Hsp40) member B4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:151866980-151867163 Neighboring gene predicted gene, 40180 Neighboring gene STARR-positive B cell enhancer ABC_E2101 Neighboring gene STARR-seq mESC enhancer starr_09284 Neighboring gene nexilin Neighboring gene STARR-positive B cell enhancer mm9_chr3:151922476-151922776 Neighboring gene predicted gene, 31999

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
far upstream element-binding protein 1
Names
FUSE-binding protein 1
far upstream element (FUSE) binding protein 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355366.2NP_001342295.1  far upstream element-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123075
    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (2) summary
    cd00105
    Location:295356
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:119183
    KH_1; KH domain
  2. NM_001355367.2NP_001342296.1  far upstream element-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123075
    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (2) summary
    cd00105
    Location:294355
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:118182
    KH_1; KH domain
  3. NM_001355368.2NP_001342297.1  far upstream element-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123075
    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (2) summary
    cd00105
    Location:295356
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:119183
    KH_1; KH domain
  4. NM_001355369.2NP_001342298.1  far upstream element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Consensus CDS
    CCDS89708.1
    UniProtKB/TrEMBL
    A0A0G2JFY5, Q3TIS5
    Related
    ENSMUSP00000143354.2, ENSMUST00000200524.5
    Conserved Domains (2) summary
    cd00105
    Location:274335
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:98162
    KH_1; KH domain
  5. NM_001355370.2NP_001342299.1  far upstream element-binding protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123075
    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (2) summary
    cd00105
    Location:273334
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:97161
    KH_1; KH domain
  6. NM_001355371.2NP_001342300.1  far upstream element-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Consensus CDS
    CCDS89707.1
    UniProtKB/Swiss-Prot
    Q8C0Y8, Q91WJ8
    UniProtKB/TrEMBL
    Q3TIS5
    Related
    ENSMUSP00000143101.2, ENSMUST00000196739.5
    Conserved Domains (2) summary
    cd00105
    Location:274335
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:98162
    KH_1; KH domain
  7. NM_001355372.2NP_001342301.1  far upstream element-binding protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Consensus CDS
    CCDS89709.1
    UniProtKB/TrEMBL
    A0A0G2JGW9, Q3TIS5
    Related
    ENSMUSP00000143729.2, ENSMUST00000196695.5
    Conserved Domains (2) summary
    cd00105
    Location:274335
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:98162
    KH_1; KH domain
  8. NM_001355373.2NP_001342302.1  far upstream element-binding protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC123075
    UniProtKB/TrEMBL
    Q0P6B2, Q3TIS5
    Conserved Domains (5) summary
    pfam09005
    Location:604618
    DUF1897; Domain of unknown function (DUF1897)
    cd22478
    Location:94168
    KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    cd22481
    Location:182251
    KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    cd22484
    Location:272339
    KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    cd22487
    Location:372443
    KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
  9. NM_001355374.2NP_001342303.1  far upstream element-binding protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC123075
    UniProtKB/TrEMBL
    Q3TIS5
    Related
    ENSMUSP00000143370.2, ENSMUST00000198227.5
    Conserved Domains (2) summary
    cd00105
    Location:273334
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:97161
    KH_1; KH domain
  10. NM_001428764.1NP_001415693.1  far upstream element-binding protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC123075
  11. NM_057172.5NP_476513.2  far upstream element-binding protein 1 isoform 8

    See identical proteins and their annotated locations for NP_476513.2

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Consensus CDS
    CCDS38672.1
    UniProtKB/TrEMBL
    Q3TIS5, Q3TUE1
    Related
    ENSMUSP00000130145.2, ENSMUST00000166984.8
    Conserved Domains (2) summary
    cd00105
    Location:97159
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam09005
    Location:606620
    DUF1897; Domain of unknown function (DUF1897)

RNA

  1. NR_149713.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123075
    Related
    ENSMUST00000199876.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    151916059..151942467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501672.2XP_006501735.1  far upstream element-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (3) summary
    cd00105
    Location:97159
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:376440
    KH_1; KH domain
    pfam09005
    Location:603617
    DUF1897; Domain of unknown function (DUF1897)
  2. XM_036163154.1XP_036019047.1  far upstream element-binding protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (5) summary
    pfam09005
    Location:603617
    DUF1897; Domain of unknown function (DUF1897)
    cd22478
    Location:93167
    KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    cd22481
    Location:181250
    KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    cd22484
    Location:271338
    KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    cd22487
    Location:371442
    KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
  3. XM_006501663.2XP_006501726.1  far upstream element-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (3) summary
    cd00105
    Location:119181
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:398462
    KH_1; KH domain
    pfam09005
    Location:628642
    DUF1897; Domain of unknown function (DUF1897)
  4. XM_006501664.2XP_006501727.1  far upstream element-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (3) summary
    cd00105
    Location:119181
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:398462
    KH_1; KH domain
    pfam09005
    Location:628642
    DUF1897; Domain of unknown function (DUF1897)
  5. XM_006501660.2XP_006501723.1  far upstream element-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (3) summary
    cd00105
    Location:119181
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:398462
    KH_1; KH domain
    pfam09005
    Location:628642
    DUF1897; Domain of unknown function (DUF1897)
  6. XM_030252673.1XP_030108533.1  far upstream element-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (3) summary
    cd00105
    Location:119181
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:398462
    KH_1; KH domain
    pfam09005
    Location:625639
    DUF1897; Domain of unknown function (DUF1897)
  7. XM_006501662.2XP_006501725.1  far upstream element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3TIS5
    Conserved Domains (3) summary
    cd00105
    Location:119181
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:398462
    KH_1; KH domain
    pfam09005
    Location:625639
    DUF1897; Domain of unknown function (DUF1897)
  8. XM_030252674.2XP_030108534.1  far upstream element-binding protein 1 isoform X7

    Conserved Domains (3) summary
    cd00105
    Location:118180
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:397461
    KH_1; KH domain
    pfam09005
    Location:624638
    DUF1897; Domain of unknown function (DUF1897)

RNA

  1. XR_001783710.2 RNA Sequence

  2. XR_003954356.2 RNA Sequence

  3. XR_001783712.2 RNA Sequence

  4. XR_004941359.1 RNA Sequence

  5. XR_001783711.3 RNA Sequence

  6. XR_004941352.1 RNA Sequence

  7. XR_001783705.2 RNA Sequence

  8. XR_001783706.2 RNA Sequence

  9. XR_003954350.1 RNA Sequence

  10. XR_004941353.1 RNA Sequence

  11. XR_004941358.1 RNA Sequence

  12. XR_003954355.1 RNA Sequence

  13. XR_375543.4 RNA Sequence

  14. XR_001783714.2 RNA Sequence

  15. XR_004941356.1 RNA Sequence

  16. XR_001783708.2 RNA Sequence

  17. XR_001783709.2 RNA Sequence

  18. XR_004941354.1 RNA Sequence

  19. XR_004941357.1 RNA Sequence

  20. XR_001783707.3 RNA Sequence

  21. XR_004941355.1 RNA Sequence