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GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 51809, updated on 3-May-2020

Summary

Official Symbol
GALNT7provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:4129
See related
Ensembl:ENSG00000109586 MIM:605005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GalNAcT7; GALNAC-T7
Summary
This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 19.2), colon (RPKM 18.8) and 23 other tissues See more
Orthologs

Genomic context

See GALNT7 in Genome Data Viewer
Location:
4q34.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (173168811..173323967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174089904..174245118)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase like 6 Neighboring gene uncharacterized LOC107986201 Neighboring gene uncharacterized LOC101930370 Neighboring gene RNA, 7SL, cytoplasmic 253, pseudogene Neighboring gene uncharacterized LOC105377541 Neighboring gene microRNA 548t Neighboring gene high mobility group box 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
protein O-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
N-acetylgalactosaminyltransferase 7
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
polypeptide GalNAc transferase 7
pp-GaNTase 7
protein-UDP acetylgalactosaminyltransferase 7
NP_001362528.1
NP_001362529.1
NP_001362530.1
NP_059119.2
XP_011530327.1
XP_016863781.1
XP_016863782.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375599.1NP_001362528.1  N-acetylgalactosaminyltransferase 7 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC097534, AC105285
  2. NM_001375600.1NP_001362529.1  N-acetylgalactosaminyltransferase 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC097534, AC105285
  3. NM_001375601.1NP_001362530.1  N-acetylgalactosaminyltransferase 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC097534, AC105285
  4. NM_017423.3NP_059119.2  N-acetylgalactosaminyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_059119.2

    Status: REVIEWED

    Source sequence(s)
    AJ002744, BC035303, BC046129, BC047468
    Consensus CDS
    CCDS3815.1
    UniProtKB/Swiss-Prot
    Q86SF2
    Related
    ENSP00000265000.4, ENST00000265000.9
    Conserved Domains (2) summary
    cd02510
    Location:210518
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:534649
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    173168811..173323967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008293.1XP_016863782.1  N-acetylgalactosaminyltransferase 7 isoform X3

  2. XM_017008292.2XP_016863781.1  N-acetylgalactosaminyltransferase 7 isoform X2

  3. XM_011532025.3XP_011530327.1  N-acetylgalactosaminyltransferase 7 isoform X4

    Conserved Domains (4) summary
    cd02510
    Location:169477
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:169290
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:494610
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:493608
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
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