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PHAX phosphorylated adaptor for RNA export [ Homo sapiens (human) ]

Gene ID: 51808, updated on 6-Sep-2022

Summary

Official Symbol
PHAXprovided by HGNC
Official Full Name
phosphorylated adaptor for RNA exportprovided by HGNC
Primary source
HGNC:HGNC:10241
See related
Ensembl:ENSG00000164902 MIM:604924; AllianceGenome:HGNC:10241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNUXA
Summary
Enables mRNA cap binding complex binding activity. Involved in RNA stabilization. Located in centrosome and nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 11.7), endometrium (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See PHAX in Genome Data Viewer
Location:
5q23.2
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (126600947..126627252)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (127117809..127144117)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (125936639..125962944)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10286 Neighboring gene aldehyde dehydrogenase 7 family member A1 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 7 Neighboring gene testis expressed 43

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA cap binding complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables toxic substance binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in snRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA export from nucleus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosphorylated adapter RNA export protein
Names
RNA U small nuclear RNA export adapter protein
RNA U, small nuclear RNA export adapter (phosphorylation regulated)
RNA U, small nuclear RNA export adaptor (phosphorylation regulated)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032177.4NP_115553.2  phosphorylated adapter RNA export protein

    See identical proteins and their annotated locations for NP_115553.2

    Status: VALIDATED

    Source sequence(s)
    AC099513, AK023255, BC021161
    Consensus CDS
    CCDS4138.1
    UniProtKB/Swiss-Prot
    Q9H814, Q9H8W1
    Related
    ENSP00000297540.4, ENST00000297540.5
    Conserved Domains (1) summary
    pfam10258
    Location:230313
    RNA_GG_bind; PHAX RNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    126600947..126627252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    127117809..127144117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)