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TUBA8 tubulin alpha 8 [ Homo sapiens (human) ]

Gene ID: 51807, updated on 13-Mar-2020

Summary

Official Symbol
TUBA8provided by HGNC
Official Full Name
tubulin alpha 8provided by HGNC
Primary source
HGNC:HGNC:12410
See related
Ensembl:ENSG00000183785 MIM:605742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDCBM8; TUBAL2
Summary
This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Expression
Biased expression in heart (RPKM 36.8), testis (RPKM 14.8) and 3 other tissues See more
Orthologs

Genomic context

See TUBA8 in Genome Data Viewer
Location:
22q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (18110809..18131732)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18593453..18614498)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372853 Neighboring gene peroxisomal biogenesis factor 26 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 10 Neighboring gene ubiquitin specific peptidase 18 Neighboring gene family with sequence similarity 230 member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tubulin, alpha 8 (TUBA8) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion PubMed
Rev rev HIV-1 Rev interacting protein, TUBA8, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
rev Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection PubMed
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed
tat HIV-1 Tat causes a dramatic decrease in alpha-tubulin staining, which indicates disruption of the cytoskeleton organization in human intestinal epithelial cells PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
integrase gag-pol Co-immunoprecipitation shows interaction of HIV-1 IN with alpha-tubulin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tubulin alpha-8 chain
Names
tubulin alpha chain-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023429.1 RefSeqGene

    Range
    5123..26047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193414.2NP_001180343.1  tubulin alpha-8 chain isoform 2

    See identical proteins and their annotated locations for NP_001180343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008079, AJ245922, AK056947
    Consensus CDS
    CCDS54495.1
    UniProtKB/Swiss-Prot
    Q9NY65
    Related
    ENSP00000318575.6, ENST00000316027.10
    Conserved Domains (1) summary
    PTZ00335
    Location:1373
    PTZ00335; tubulin alpha chain; Provisional
  2. NM_018943.3NP_061816.1  tubulin alpha-8 chain isoform 1

    See identical proteins and their annotated locations for NP_061816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008079, AJ245922, DA059342
    Consensus CDS
    CCDS13751.1
    UniProtKB/Swiss-Prot
    Q9NY65
    Related
    ENSP00000333326.3, ENST00000330423.8
    Conserved Domains (1) summary
    PTZ00335
    Location:1439
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    18110809..18131732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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