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Rundc3a RUN domain containing 3A [ Mus musculus (house mouse) ]

Gene ID: 51799, updated on 26-Sep-2022

Summary

Official Symbol
Rundc3aprovided by MGI
Official Full Name
RUN domain containing 3Aprovided by MGI
Primary source
MGI:MGI:1858752
See related
Ensembl:ENSMUSG00000006575 AllianceGenome:MGI:1858752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpip8; RPIP-8; Rap2ip
Summary
Predicted to be involved in positive regulation of cGMP-mediated signaling. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; gut; nervous system; nose; and retina. Orthologous to human RUNDC3A (RUN domain containing 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 61.8), frontal lobe adult (RPKM 60.5) and 10 other tissues See more
Orthologs
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Genomic context

See Rundc3a in Genome Data Viewer
Location:
11; 11 D
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102284219..102293381)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102393394..102402555)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 (anion exchanger), member 1 Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene solute carrier family 25, member 39 Neighboring gene microRNA 6930 Neighboring gene granulin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RUN domain-containing protein 3A
Names
Rap2 interacting protein 8
rap2-interacting protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252347.2NP_001239276.1  RUN domain-containing protein 3A isoform 2

    See identical proteins and their annotated locations for NP_001239276.1

    Status: VALIDATED

    Source sequence(s)
    AL596258, BC046319, BY277835
    Consensus CDS
    CCDS56812.1
    UniProtKB/Swiss-Prot
    O08576
    Related
    ENSMUSP00000102722.3, ENSMUST00000107105.9
    Conserved Domains (2) summary
    pfam02759
    Location:60188
    RUN; RUN domain
    cl09111
    Location:255315
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. NM_001362803.1NP_001349732.1  RUN domain-containing protein 3A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596258
    Conserved Domains (1) summary
    pfam02759
    Location:60182
    RUN; RUN domain
  3. NM_001362804.1NP_001349733.1  RUN domain-containing protein 3A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596258
    Conserved Domains (2) summary
    pfam02759
    Location:60186
    RUN; RUN domain
    pfam11180
    Location:263321
    DUF2968; Protein of unknown function (DUF2968)
  4. NM_016759.5NP_058039.1  RUN domain-containing protein 3A isoform 1

    See identical proteins and their annotated locations for NP_058039.1

    Status: VALIDATED

    Source sequence(s)
    AK002856, AL596258, BC046319, BY277835
    Consensus CDS
    CCDS25497.1
    UniProtKB/Swiss-Prot
    O08576, Q80Y95
    Related
    ENSMUSP00000006750.8, ENSMUST00000006750.8
    Conserved Domains (2) summary
    pfam02759
    Location:60188
    RUN; RUN domain
    pfam15898
    Location:267321
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102284219..102293381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533690.2XP_006533753.1  RUN domain-containing protein 3A isoform X3

    Conserved Domains (2) summary
    pfam02759
    Location:60186
    RUN; RUN domain
    pfam06785
    Location:255318
    UPF0242; Uncharacterized protein family (UPF0242)
  2. XM_006533693.4XP_006533756.1  RUN domain-containing protein 3A isoform X10

    UniProtKB/Swiss-Prot
    O08576
    Related
    ENSMUSP00000102719.2, ENSMUST00000107102.8
    Conserved Domains (2) summary
    pfam02759
    Location:60186
    RUN; RUN domain
    pfam06785
    Location:255318
    UPF0242; Uncharacterized protein family (UPF0242)
  3. XM_030246121.2XP_030101981.1  RUN domain-containing protein 3A isoform X7

    Conserved Domains (2) summary
    pfam02759
    Location:60181
    RUN; RUN domain
    pfam06785
    Location:250313
    UPF0242; Uncharacterized protein family (UPF0242)
  4. XM_006533688.2XP_006533751.1  RUN domain-containing protein 3A isoform X1

    Conserved Domains (2) summary
    pfam02759
    Location:60197
    RUN; RUN domain
    pfam06785
    Location:266329
    UPF0242; Uncharacterized protein family (UPF0242)
  5. XM_017314648.3XP_017170137.1  RUN domain-containing protein 3A isoform X9

    Conserved Domains (2) summary
    pfam02759
    Location:60197
    RUN; RUN domain
    pfam06785
    Location:266329
    UPF0242; Uncharacterized protein family (UPF0242)
  6. XM_006533689.3XP_006533752.1  RUN domain-containing protein 3A isoform X2

    Conserved Domains (2) summary
    pfam02759
    Location:60197
    RUN; RUN domain
    pfam06785
    Location:266329
    UPF0242; Uncharacterized protein family (UPF0242)
  7. XM_006533691.2XP_006533754.1  RUN domain-containing protein 3A isoform X4

    Conserved Domains (2) summary
    pfam02759
    Location:60182
    RUN; RUN domain
    pfam06785
    Location:251314
    UPF0242; Uncharacterized protein family (UPF0242)
  8. XM_017314647.3XP_017170136.1  RUN domain-containing protein 3A isoform X6

    Conserved Domains (2) summary
    pfam02759
    Location:60182
    RUN; RUN domain
    pfam06785
    Location:251314
    UPF0242; Uncharacterized protein family (UPF0242)
  9. XM_006533692.2XP_006533755.1  RUN domain-containing protein 3A isoform X5

    Conserved Domains (2) summary
    pfam02759
    Location:60181
    RUN; RUN domain
    pfam06785
    Location:250313
    UPF0242; Uncharacterized protein family (UPF0242)
  10. XM_006533694.4XP_006533757.1  RUN domain-containing protein 3A isoform X11

    UniProtKB/Swiss-Prot
    O08576
    Related
    ENSMUSP00000102720.2, ENSMUST00000107103.8
    Conserved Domains (2) summary
    pfam02759
    Location:60181
    RUN; RUN domain
    pfam06785
    Location:250313
    UPF0242; Uncharacterized protein family (UPF0242)
  11. XM_011249124.2XP_011247426.1  RUN domain-containing protein 3A isoform X8

    Conserved Domains (2) summary
    pfam02759
    Location:60197
    RUN; RUN domain
    pfam06785
    Location:266329
    UPF0242; Uncharacterized protein family (UPF0242)

RNA

  1. XR_003949474.2 RNA Sequence

  2. XR_003949475.2 RNA Sequence

  3. XR_001780024.2 RNA Sequence

  4. XR_003949473.2 RNA Sequence

  5. XR_004936988.1 RNA Sequence

  6. XR_003949476.2 RNA Sequence