U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H2az1 H2A.Z variant histone 1 [ Mus musculus (house mouse) ]

Gene ID: 51788, updated on 26-Sep-2022

Summary

Official Symbol
H2az1provided by MGI
Official Full Name
H2A.Z variant histone 1provided by MGI
Primary source
MGI:MGI:1888388
See related
Ensembl:ENSMUSG00000037894 AllianceGenome:MGI:1888388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2A.Z; H2afz; H2A.Z1; H2a.z-1
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression
Broad expression in CNS E11.5 (RPKM 475.3), liver E14 (RPKM 375.3) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H2az1 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137570248..137572683)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137864487..137866922)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31678 Neighboring gene predicted gene 43403 Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene predicted gene, 40155 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleosomal DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NOT located_in Barr body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
histone H2A.Z
Names
H2A histone family, member Z

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316995.1NP_001303924.1  histone H2A.Z isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC125154
    Consensus CDS
    CCDS84676.1
    UniProtKB/TrEMBL
    Q3UA95
    Related
    ENSMUSP00000134059.2, ENSMUST00000174561.8
    Conserved Domains (1) summary
    PLN00154
    Location:698
    PLN00154; histone H2A; Provisional
  2. NM_016750.3NP_058030.1  histone H2A.Z isoform 1

    See identical proteins and their annotated locations for NP_058030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC125154
    Consensus CDS
    CCDS38647.1
    UniProtKB/Swiss-Prot
    P0C0S6, Q68FD2
    UniProtKB/TrEMBL
    A0A6P5PNK8
    Related
    ENSMUSP00000036907.8, ENSMUST00000041045.14
    Conserved Domains (1) summary
    PLN00154
    Location:6121
    PLN00154; histone H2A; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137570248..137572683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)