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RSF1 remodeling and spacing factor 1 [ Homo sapiens (human) ]

Gene ID: 51773, updated on 5-Sep-2021

Summary

Official Symbol
RSF1provided by HGNC
Official Full Name
remodeling and spacing factor 1provided by HGNC
Primary source
HGNC:HGNC:18118
See related
Ensembl:ENSG00000048649 MIM:608522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XAP8; p325; HBXAP; RSF-1
Summary
This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in adrenal (RPKM 7.3), thyroid (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See RSF1 in Genome Data Viewer
Location:
11q14.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (77660009..77872232, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77377274..77531880, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984369 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4537 Neighboring gene chloride nucleotide-sensitive channel 1A Neighboring gene ferritin heavy chain 1 pseudogene 16 Neighboring gene ribosomal protein S20 pseudogene 27 Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene ribosomal protein L21 pseudogene 95 Neighboring gene integrator complex subunit 4 Neighboring gene NDUFC2-KCTD14 readthrough Neighboring gene potassium channel tetramerization domain containing 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of RSF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RSF complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
remodeling and spacing factor 1
Names
HBV pX-associated protein 8
hepatitis B virus x-associated protein
p325 subunit of RSF chromatin-remodeling complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016578.4NP_057662.3  remodeling and spacing factor 1

    See identical proteins and their annotated locations for NP_057662.3

    Status: VALIDATED

    Source sequence(s)
    AP000580, AP000609, AP002343
    Consensus CDS
    CCDS8253.1
    UniProtKB/Swiss-Prot
    Q96T23
    UniProtKB/TrEMBL
    Q05DG0
    Related
    ENSP00000311513.6, ENST00000308488.11
    Conserved Domains (5) summary
    cd15543
    Location:893938
    PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
    pfam02724
    Location:10931171
    CDC45; CDC45-like protein
    pfam15612
    Location:98148
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:150182
    WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
    cl02608
    Location:915968
    BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    77660009..77872232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274051.2XP_005274108.1  remodeling and spacing factor 1 isoform X1

    Conserved Domains (5) summary
    cd15543
    Location:890935
    PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
    pfam02724
    Location:10901168
    CDC45; CDC45-like protein
    pfam15612
    Location:98148
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:150182
    WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
    cl02608
    Location:912965
    BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  2. XM_017017923.1XP_016873412.1  remodeling and spacing factor 1 isoform X2

    Related
    ENSP00000434509.1, ENST00000480887.5
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