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INPP5K inositol polyphosphate-5-phosphatase K [ Homo sapiens (human) ]

Gene ID: 51763, updated on 7-Oct-2018

Summary

Official Symbol
INPP5Kprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Kprovided by HGNC
Primary source
HGNC:HGNC:33882
See related
Ensembl:ENSG00000132376 MIM:607875; Vega:OTTHUMG00000150648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPS; SKIP; MDCCAID
Summary
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in fat (RPKM 17.9), lung (RPKM 14.5) and 25 other tissues See more
Orthologs

Genomic context

See INPP5K in Genome Data Viewer
Location:
17p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (1494575..1516888, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1397869..1420182, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene myosin IC Neighboring gene uncharacterized LOC105371483 Neighboring gene PITPNA antisense RNA 1 Neighboring gene phosphatidylinositol transfer protein alpha Neighboring gene solute carrier family 43 member 2 Neighboring gene RNA, 7SL, cytoplasmic 105, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inositol bisphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol bisphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol trisphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
lipid phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylinositol phosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol trisphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
vasopressin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasopressin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epidermal growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
in utero embryonic development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation by host of viral transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glycogen (starch) synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glycogen (starch) synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of renal water transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of renal water transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of urine volume IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of urine volume ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inositol polyphosphate 5-phosphatase K
Names
skeletal muscle and kidney-enriched inositol phosphatase
NP_001129114.1
NP_057616.2
NP_570122.1
XP_005256740.1
XP_005256742.1
XP_005256743.1
XP_011522236.1
XP_011522238.1
XP_016880245.1
XP_016880246.1
XP_016880247.1
XP_016880248.1
XP_024306570.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029891.1 RefSeqGene

    Range
    5001..27312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135642.1NP_001129114.1  inositol polyphosphate 5-phosphatase K isoform 2

    See identical proteins and their annotated locations for NP_001129114.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional segment in its 5' end, as compared to variant 1. The resulting isoform, isoform 2, has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform, isoform 2.
    Source sequence(s)
    AB036829, AC100748, AK312844, BC004362, BG722885, BM510617
    Consensus CDS
    CCDS11005.1
    UniProtKB/Swiss-Prot
    Q9BT40
    Related
    ENSP00000385177.4, OTTHUMP00000198134, ENST00000406424.8, OTTHUMT00000319383
    Conserved Domains (1) summary
    cl00490
    Location:1244
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. NM_016532.3NP_057616.2  inositol polyphosphate 5-phosphatase K isoform 1

    See identical proteins and their annotated locations for NP_057616.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform of this protein.
    Source sequence(s)
    AB036829, AC100748, AK312844, BC004362, BG722885, BM510617
    Consensus CDS
    CCDS11004.1
    UniProtKB/Swiss-Prot
    Q9BT40
    Related
    ENSP00000413937.2, OTTHUMP00000198132, ENST00000421807.6, OTTHUMT00000319381
    Conserved Domains (1) summary
    cl00490
    Location:14320
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. NM_130766.2NP_570122.1  inositol polyphosphate 5-phosphatase K isoform 2

    See identical proteins and their annotated locations for NP_570122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in its 5' end, as compared to variant 1. The resulting isoform, isoform 2, has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform, isoform 2.
    Source sequence(s)
    AB036829, AC100748, AK312844, BC004362, BG722885, BM510617
    Consensus CDS
    CCDS11005.1
    UniProtKB/Swiss-Prot
    Q9BT40
    Related
    ENSP00000318476.6, OTTHUMP00000198135, ENST00000320345.10, OTTHUMT00000319384
    Conserved Domains (1) summary
    cl00490
    Location:1244
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    1494575..1516888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256683.2XP_005256740.1  inositol polyphosphate 5-phosphatase K isoform X1

    See identical proteins and their annotated locations for XP_005256740.1

    UniProtKB/Swiss-Prot
    Q9BT40
    Conserved Domains (1) summary
    cl00490
    Location:1244
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. XM_011523936.2XP_011522238.1  inositol polyphosphate 5-phosphatase K isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:51185
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. XM_017024758.2XP_016880247.1  inositol polyphosphate 5-phosphatase K isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:51185
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  4. XM_005256686.2XP_005256743.1  inositol polyphosphate 5-phosphatase K isoform X2

    See identical proteins and their annotated locations for XP_005256743.1

    UniProtKB/TrEMBL
    B7Z4V9
    Conserved Domains (1) summary
    cl00490
    Location:1228
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  5. XM_024450802.1XP_024306570.1  inositol polyphosphate 5-phosphatase K isoform X1

    Conserved Domains (1) summary
    cl00490
    Location:1244
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  6. XM_011523934.1XP_011522236.1  inositol polyphosphate 5-phosphatase K isoform X1

    See identical proteins and their annotated locations for XP_011522236.1

    UniProtKB/Swiss-Prot
    Q9BT40
    Conserved Domains (1) summary
    cl00490
    Location:1244
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  7. XM_017024756.1XP_016880245.1  inositol polyphosphate 5-phosphatase K isoform X1

    UniProtKB/Swiss-Prot
    Q9BT40
    Conserved Domains (1) summary
    cl00490
    Location:1244
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  8. XM_017024757.2XP_016880246.1  inositol polyphosphate 5-phosphatase K isoform X2

    UniProtKB/TrEMBL
    B7Z4V9
    Conserved Domains (1) summary
    cl00490
    Location:1228
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  9. XM_005256685.1XP_005256742.1  inositol polyphosphate 5-phosphatase K isoform X2

    See identical proteins and their annotated locations for XP_005256742.1

    UniProtKB/TrEMBL
    B7Z4V9
    Conserved Domains (1) summary
    cl00490
    Location:1228
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  10. XM_017024759.1XP_016880248.1  inositol polyphosphate 5-phosphatase K isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:51185
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
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