ADAM17 ADAM metallopeptidase domain 17 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ADAM17provided by VGNC
Official Full Name: ADAM metallopeptidase domain 17provided by VGNC
Primary source: VGNC:VGNC:25607
See related: BGD:BT26034; EnsemblRapid:ENSBTAG00070006837
Gene type: protein coding
RefSeq status: MODEL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (87917595..87961887)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

RM363 (e-PCR), detects polymorphism
- UniSTS:2678

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 17

XP_002691532.1

EC 3.4.24.86

XP_059747809.1

EC 3.4.24.86

XP_059747810.1

EC 3.4.24.86

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

Range

87917595..87961887

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002691486.7 → XP_002691532.1 disintegrin and metalloproteinase domain-containing protein 17 isoform X1

See identical proteins and their annotated locations for XP_002691532.1

UniProtKB/TrEMBL

A0AAA9RZV6, A0AAA9SM15

Related

ENSBTAP00070008855.1, ENSBTAT00070015551.1

Conserved Domains (4) summary

smart00050
Location:482 → 558

DISIN; Homologues of snake disintegrins

cd04270
Location:221 → 475

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:54 → 150

Pep_M12B_propep; Reprolysin family propeptide

pfam16698
Location:579 → 639

ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
XM_059891826.1 → XP_059747809.1 disintegrin and metalloproteinase domain-containing protein 17 isoform X2
XM_059891827.1 → XP_059747810.1 disintegrin and metalloproteinase domain-containing protein 17 isoform X3