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POLR3K RNA polymerase III subunit K [ Homo sapiens (human) ]

Gene ID: 51728, updated on 24-Nov-2020

Summary

Official Symbol
POLR3Kprovided by HGNC
Official Full Name
RNA polymerase III subunit Kprovided by HGNC
Primary source
HGNC:HGNC:14121
See related
Ensembl:ENSG00000161980 MIM:606007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11; My010; RPC10; RPC11; RPC12.5; C11-RNP3
Summary
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in lymph node (RPKM 13.5), appendix (RPKM 11.4) and 25 other tissues See more
Orthologs

Genomic context

See POLR3K in Genome Data Viewer
Location:
16p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (46407..53608, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (96979..103632, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene WASH and IL9R antisense RNA 2 Neighboring gene interleukin 9 receptor pseudogene 3 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 25 Neighboring gene rhomboid 5 homolog 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
tRNA 3'-trailer cleavage IEA
Inferred from Electronic Annotation
more info
 
termination of RNA polymerase III transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase III TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC10
Names
DNA-directed RNA polymerase III subunit K
DNA-directed RNA polymerases III 12.5 kDa polypeptide
RNA polymerase III 12.5 kDa subunit
RNA polymerase III subunit C10
RNA polymerase III subunit C11
RNA polymerase III subunit CII
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
polymerase (RNA) III subunit K
NP_057394.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016310.5NP_057394.3  DNA-directed RNA polymerase III subunit RPC10

    See identical proteins and their annotated locations for NP_057394.3

    Status: REVIEWED

    Source sequence(s)
    BC011932, DR978472, KF456133, Z69719
    Consensus CDS
    CCDS10395.1
    UniProtKB/Swiss-Prot
    Q9Y2Y1
    Related
    ENSP00000293860.5, ENST00000293860.6
    Conserved Domains (2) summary
    COG1594
    Location:1108
    RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
    cd10509
    Location:61108
    Zn-ribbon_RPC11; C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    46407..53608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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