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CMPK1 cytidine/uridine monophosphate kinase 1 [ Homo sapiens (human) ]

Gene ID: 51727, updated on 7-Apr-2019

Summary

Official Symbol
CMPK1provided by HGNC
Official Full Name
cytidine/uridine monophosphate kinase 1provided by HGNC
Primary source
HGNC:HGNC:18170
See related
Ensembl:ENSG00000162368 MIM:191710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK; CMK; UMK; CMPK; UMPK; UMP-CMPK
Summary
This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in colon (RPKM 74.1), duodenum (RPKM 71.2) and 25 other tissues See more
Orthologs

Genomic context

See CMPK1 in Genome Data Viewer
Location:
1p33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (47333797..47378839)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47799469..47844511)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TAL bHLH transcription factor 1, erythroid differentiation factor Neighboring gene STIL centriolar assembly protein Neighboring gene long intergenic non-protein coding RNA 1389 Neighboring gene forkhead box E3 Neighboring gene FOXD2 adjacent opposite strand RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cytidylate kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
uridine kinase activity TAS
Traceable Author Statement
more info
PubMed 
uridylate kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside diphosphate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
nucleoside triphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
pyrimidine ribonucleotide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
UMP-CMP kinase
Names
UMP/CMP kinase
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
cytidylate kinase
dCMP kinase
deoxycytidylate kinase
nucleoside-diphosphate kinase
uridine monophosphate kinase
uridine monophosphate/cytidine monophosphate kinase
NP_001129612.1
NP_057392.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136140.1NP_001129612.1  UMP-CMP kinase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF070416, AL513322, AL607122, DB494965
    Consensus CDS
    CCDS44135.1
    UniProtKB/Swiss-Prot
    P30085
    Related
    ENSP00000398192.2, ENST00000450808.2
    Conserved Domains (2) summary
    cd01428
    Location:37167
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01359
    Location:37176
    UMP_CMP_kin_fam; UMP-CMP kinase family
  2. NM_001366135.1NP_001353064.1  UMP-CMP kinase isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform c.
    Source sequence(s)
    AL513322, AL607122
    Conserved Domains (1) summary
    cl27057
    Location:5193
    ADK; Adenylate kinase
  3. NM_016308.3NP_057392.1  UMP-CMP kinase isoform a

    See identical proteins and their annotated locations for NP_057392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL513322, AL607122
    Consensus CDS
    CCDS549.1
    UniProtKB/Swiss-Prot
    P30085
    UniProtKB/TrEMBL
    B2R6S5
    Related
    ENSP00000360939.5, ENST00000371873.9
    Conserved Domains (2) summary
    cd01428
    Location:37216
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01359
    Location:37225
    UMP_CMP_kin_fam; UMP-CMP kinase family

RNA

  1. NR_046394.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL513322, AL607122
  2. NR_046395.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, found in variant 1.
    Source sequence(s)
    AL513322, AL607122
    Related
    ENST00000471289.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    47333797..47378839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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