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DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 [ Homo sapiens (human) ]

Gene ID: 51726, updated on 25-Nov-2021

Summary

Official Symbol
DNAJB11provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B11provided by HGNC
Primary source
HGNC:HGNC:14889
See related
Ensembl:ENSG00000090520 MIM:611341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJ9; EDJ; Dj-9; ERj3; PKD6; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080
Summary
This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in thyroid (RPKM 37.3), appendix (RPKM 33.9) and 25 other tissues See more
Orthologs
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Genomic context

See DNAJB11 in Genome Data Viewer
Location:
3q27.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (186570720..186585793)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186288509..186303582)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene crystallin gamma S Neighboring gene Sharpr-MPRA regulatory region 2674 Neighboring gene TBCC domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 9080 Neighboring gene uncharacterized LOC100287402 Neighboring gene alpha 2-HS glycoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with DNAJB11; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed
env HIV-1 gp160 is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mRNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chaperone complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
part_of endoplasmic reticulum chaperone complex IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 11
Names
APOBEC1-binding protein 2
DnaJ (Hsp40) homolog, subfamily B, member 11
DnaJ protein 9
ER-associated DNAJ protein 3
ER-associated Hsp40 co-chaperone
ER-resident protein ERdj3
PWP1-interacting protein 4
endoplasmic reticulum DNA J domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034024.1 RefSeqGene

    Range
    5001..20125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001378451.1NP_001365380.1  dnaJ homolog subfamily B member 11 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Conserved Domains (1) summary
    COG0484
    Location:22252
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  2. NM_016306.6NP_057390.1  dnaJ homolog subfamily B member 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC068631
    Consensus CDS
    CCDS3277.1
    UniProtKB/Swiss-Prot
    Q9UBS4
    Related
    ENSP00000265028.3, ENST00000265028.8
    Conserved Domains (1) summary
    COG0484
    Location:22344
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RNA

  1. NR_165638.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Related
    ENST00000680338.1
  2. NR_165639.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068631
  3. NR_165640.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068631
  4. NR_165641.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068631
  5. NR_165642.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068631
  6. NR_165643.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068631

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    186570720..186585793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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