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UIMC1 ubiquitin interaction motif containing 1 [ Homo sapiens (human) ]

Gene ID: 51720, updated on 9-Jun-2025
Official Symbol
UIMC1provided by HGNC
Official Full Name
ubiquitin interaction motif containing 1provided by HGNC
Primary source
HGNC:HGNC:30298
See related
Ensembl:ENSG00000087206 MIM:609433; AllianceGenome:HGNC:30298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAP80; X2HRIP110
Summary
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Broad expression in testis (RPKM 26.7), bone marrow (RPKM 12.5) and 24 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See UIMC1 in Genome Data Viewer
Location:
5q35.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176905005..177022602, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177450819..177566146, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176332006..176433795, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176170772-176171740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176174798-176175456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176176117-176176775 Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176211747-176212340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176212935-176213528 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:176214607-176215806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176219277-176220119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176220120-176220961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176225159-176226105 Neighboring gene MPRA-validated peak5589 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176257203-176258159 Neighboring gene unc-5 netrin receptor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176271727-176272558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176284513-176285014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176295664-176296411 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176299555-176299736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176302473-176303396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176306956-176307321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176314417-176314917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176327167-176327668 Neighboring gene hexokinase 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176370315-176371173 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176371174-176372031 Neighboring gene uncharacterized LOC124901145 Neighboring gene MPRA-validated peak5592 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449401-176449938 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449939-176450475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16670 Neighboring gene zinc finger protein 346 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:176488686-176489885 Neighboring gene FGFR4 5' regulatory region Neighboring gene fibroblast growth factor receptor 4

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
EBI GWAS Catalog
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
EBI GWAS Catalog
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-modified histone reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BRCA1-A complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
BRCA1-A complex subunit RAP80
Names
receptor-associated protein 80
retinoid X receptor-interacting protein 110

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199297.2NP_001186226.1  BRCA1-A complex subunit RAP80 isoform 1

    See identical proteins and their annotated locations for NP_001186226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK023044, BC006078, BP270983, BX537376, CF994701
    Consensus CDS
    CCDS4408.1
    UniProtKB/Swiss-Prot
    A8MSA1, B3KMZ1, B4E3N2, Q5XKQ1, Q7Z3W7, Q8N5B9, Q96RL1, Q9BZR1, Q9BZR5, Q9UHX7
  2. NM_001199298.2NP_001186227.1  BRCA1-A complex subunit RAP80 isoform 1

    See identical proteins and their annotated locations for NP_001186227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC027318, AF349313, BP270983, BX537376
    Consensus CDS
    CCDS4408.1
    UniProtKB/Swiss-Prot
    A8MSA1, B3KMZ1, B4E3N2, Q5XKQ1, Q7Z3W7, Q8N5B9, Q96RL1, Q9BZR1, Q9BZR5, Q9UHX7
    Related
    ENSP00000421926.1, ENST00000511320.6
  3. NM_001317961.1NP_001304890.1  BRCA1-A complex subunit RAP80 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR and uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC027318, BC032561, BP270983, BX537376, CF994701
    Consensus CDS
    CCDS83050.1
    UniProtKB/Swiss-Prot
    Q96RL1
    Related
    ENSP00000427480.1, ENST00000506128.5
  4. NM_016290.4NP_057374.3  BRCA1-A complex subunit RAP80 isoform 1

    See identical proteins and their annotated locations for NP_057374.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC027318, BX537376
    Consensus CDS
    CCDS4408.1
    UniProtKB/Swiss-Prot
    A8MSA1, B3KMZ1, B4E3N2, Q5XKQ1, Q7Z3W7, Q8N5B9, Q96RL1, Q9BZR1, Q9BZR5, Q9UHX7
    Related
    ENSP00000366434.4, ENST00000377227.8

RNA

  1. NR_146149.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in its 5' exon, lacks an alternate internal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027318, AF113538, AF349313, BP270983, BX537376, EF077643
  2. NR_146150.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in its 5' exon and at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027318, AK023044, BC006078, BP270983, BX537376, CF994701
    Related
    ENST00000512031.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176905005..177022602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009577.2XP_016865066.1  BRCA1-A complex subunit RAP80 isoform X4

  2. XM_006714871.3XP_006714934.1  BRCA1-A complex subunit RAP80 isoform X1

    See identical proteins and their annotated locations for XP_006714934.1

    UniProtKB/Swiss-Prot
    A8MSA1, B3KMZ1, B4E3N2, Q5XKQ1, Q7Z3W7, Q8N5B9, Q96RL1, Q9BZR1, Q9BZR5, Q9UHX7
  3. XM_005265932.4XP_005265989.1  BRCA1-A complex subunit RAP80 isoform X4

    See identical proteins and their annotated locations for XP_005265989.1

  4. XM_047417303.1XP_047273259.1  BRCA1-A complex subunit RAP80 isoform X2

  5. XM_005265933.3XP_005265990.1  BRCA1-A complex subunit RAP80 isoform X4

    See identical proteins and their annotated locations for XP_005265990.1

  6. XM_005265930.3XP_005265987.1  BRCA1-A complex subunit RAP80 isoform X1

    See identical proteins and their annotated locations for XP_005265987.1

    UniProtKB/Swiss-Prot
    A8MSA1, B3KMZ1, B4E3N2, Q5XKQ1, Q7Z3W7, Q8N5B9, Q96RL1, Q9BZR1, Q9BZR5, Q9UHX7
  7. XM_017009576.2XP_016865065.1  BRCA1-A complex subunit RAP80 isoform X4

  8. XM_047417304.1XP_047273260.1  BRCA1-A complex subunit RAP80 isoform X5

    Related
    ENSP00000423717.2, ENST00000510698.2
  9. XM_011534570.2XP_011532872.1  BRCA1-A complex subunit RAP80 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177450819..177566146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352809.1XP_054208784.1  BRCA1-A complex subunit RAP80 isoform X1

    UniProtKB/Swiss-Prot
    A8MSA1, B3KMZ1, B4E3N2, Q5XKQ1, Q7Z3W7, Q8N5B9, Q96RL1, Q9BZR1, Q9BZR5, Q9UHX7
  2. XM_054352815.1XP_054208790.1  BRCA1-A complex subunit RAP80 isoform X4

  3. XM_054352812.1XP_054208787.1  BRCA1-A complex subunit RAP80 isoform X4

  4. XM_054352810.1XP_054208785.1  BRCA1-A complex subunit RAP80 isoform X2

  5. XM_054352813.1XP_054208788.1  BRCA1-A complex subunit RAP80 isoform X4

  6. XM_054352808.1XP_054208783.1  BRCA1-A complex subunit RAP80 isoform X1

    UniProtKB/Swiss-Prot
    A8MSA1, B3KMZ1, B4E3N2, Q5XKQ1, Q7Z3W7, Q8N5B9, Q96RL1, Q9BZR1, Q9BZR5, Q9UHX7
  7. XM_054352814.1XP_054208789.1  BRCA1-A complex subunit RAP80 isoform X4

  8. XM_054352816.1XP_054208791.1  BRCA1-A complex subunit RAP80 isoform X5

  9. XM_054352811.1XP_054208786.1  BRCA1-A complex subunit RAP80 isoform X3