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CAB39 calcium binding protein 39 [ Homo sapiens (human) ]

Gene ID: 51719, updated on 17-Jun-2019

Summary

Official Symbol
CAB39provided by HGNC
Official Full Name
calcium binding protein 39provided by HGNC
Primary source
HGNC:HGNC:20292
See related
Ensembl:ENSG00000135932 MIM:612174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MO25; CGI-66
Expression
Ubiquitous expression in colon (RPKM 18.8), appendix (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See CAB39 in Genome Data Viewer
Location:
2q37.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (230712842..230821075)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231577557..231685790)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268431 Neighboring gene RNA, U6 small nuclear 451, pseudogene Neighboring gene long intergenic non-protein coding RNA 1907 Neighboring gene barrier to autointegration factor 1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 268, pseudogene Neighboring gene integral membrane protein 2C Neighboring gene GPR55 cis regulatory suppressor of immune response RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
    AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
    Endochondral Ossification, organism-specific biosystemEndochondral ossification is the process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone. During endochondral ossificatio...
  • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
    Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. This phosphorylation is immediately removed in basal conditions by PP2C, but if the cellular AMP:ATP rati...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    LKB1 signaling events, organism-specific biosystem
    LKB1 signaling events
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • PI3K Cascade, organism-specific biosystem (from REACTOME)
    PI3K Cascade, organism-specific biosystem
    PI3K Cascade
  • PKB-mediated events, organism-specific biosystem (from REACTOME)
    PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signalling, organism-specific biosystem (from REACTOME)
    mTOR signalling, organism-specific biosystemTarget of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Contr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
serine/threonine protein kinase complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
calcium-binding protein 39
Names
MO25alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130849.1NP_001124321.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, AK292382
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    Q9Y376
    UniProtKB/TrEMBL
    A0A024R496
    Related
    ENSP00000386238.3, ENST00000409788.7
    Conserved Domains (1) summary
    pfam08569
    Location:54325
    Mo25; Mo25-like
  2. NM_001130850.1NP_001124322.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AC084031, AF113536, AK000804, AK315692, DB455871
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    Q9Y376
    UniProtKB/TrEMBL
    A0A024R496
    Related
    ENSP00000386642.3, ENST00000410084.7
    Conserved Domains (1) summary
    pfam08569
    Location:54325
    Mo25; Mo25-like
  3. NM_016289.4NP_057373.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_057373.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents an alternate non-coding exon in the 5'UTR. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, BC020570, BG773506, DA886579
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    Q9Y376
    UniProtKB/TrEMBL
    A0A024R496
    Related
    ENSP00000258418.5, ENST00000258418.10
    Conserved Domains (1) summary
    pfam08569
    Location:54325
    Mo25; Mo25-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    230712842..230821075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511350.2XP_011509652.1  calcium-binding protein 39 isoform X1

    Conserved Domains (1) summary
    pfam08569
    Location:5209
    Mo25; Mo25-like
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