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CAB39 calcium binding protein 39 [ Homo sapiens (human) ]

Gene ID: 51719, updated on 6-Nov-2022

Summary

Official Symbol
CAB39provided by HGNC
Official Full Name
calcium binding protein 39provided by HGNC
Primary source
HGNC:HGNC:20292
See related
Ensembl:ENSG00000135932 MIM:612174; AllianceGenome:HGNC:20292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MO25; CGI-66
Summary
Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 18.8), appendix (RPKM 18.4) and 25 other tissues See more
Orthologs
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Genomic context

See CAB39 in Genome Data Viewer
Location:
2q37.1
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230712842..230821075)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (231195928..231304198)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231577557..231685790)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12127 Neighboring gene formin-like protein 16 Neighboring gene long intergenic non-protein coding RNA 1907 Neighboring gene BANF1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 268, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14077 Neighboring gene integral membrane protein 2C Neighboring gene GPR55 cis regulatory suppressor of immune response RNA

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IC
Inferred by Curator
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
part_of serine/threonine protein kinase complex IC
Inferred by Curator
more info
PubMed 
part_of serine/threonine protein kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
calcium-binding protein 39
Names
MO25alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130849.2NP_001124321.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, AK292382
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    A0A024R496
    Related
    ENSP00000386238.3, ENST00000409788.7
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  2. NM_001130850.2NP_001124322.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AC084031, AF113536, AK000804, AK315692, DB455871
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    A0A024R496
    Related
    ENSP00000386642.3, ENST00000410084.7
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  3. NM_016289.4NP_057373.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_057373.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents an alternate non-coding exon in the 5'UTR. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, BC020570, BG773506, DA886579
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    A0A024R496
    Related
    ENSP00000258418.5, ENST00000258418.10
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    230712842..230821075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007076406.1 RNA Sequence

  2. XR_007076407.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    231195928..231304198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)