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CAB39 calcium binding protein 39 [ Homo sapiens (human) ]

Gene ID: 51719, updated on 19-Sep-2024

Summary

Official Symbol
CAB39provided by HGNC
Official Full Name
calcium binding protein 39provided by HGNC
Primary source
HGNC:HGNC:20292
See related
Ensembl:ENSG00000135932 MIM:612174; AllianceGenome:HGNC:20292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MO25; CGI-66
Summary
Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 18.8), appendix (RPKM 18.4) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See CAB39 in Genome Data Viewer
Location:
2q37.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230712842..230821075)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (231195928..231304198)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231577557..231685790)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17232 Neighboring gene RNA, U6 small nuclear 451, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17236 Neighboring gene CRISPRi-validated cis-regulatory element chr2.6880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231524789-231525345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17241 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231531133-231531998 Neighboring gene Sharpr-MPRA regulatory region 12127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17247 Neighboring gene formin-like protein 16 Neighboring gene long intergenic non-protein coding RNA 1907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12412 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231585879-231586402 Neighboring gene BANF1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17248 Neighboring gene RNA, U6 small nuclear 268, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231654665-231655164 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:231657991-231659190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12413 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:231708391-231709016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231726605-231727215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231728341-231728999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231729658-231730316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231730317-231730973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231734265-231734922 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231734923-231735580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231742513-231743287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231757691-231758270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231758271-231758850 Neighboring gene integral membrane protein 2C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12419 Neighboring gene GPR55 cis regulatory suppressor of immune response RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
part_of serine/threonine protein kinase complex IC
Inferred by Curator
more info
PubMed 
part_of serine/threonine protein kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of serine/threonine protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
calcium-binding protein 39
Names
MO25alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130849.2NP_001124321.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, AK292382
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    Q7Z4X0
    Related
    ENSP00000386238.3, ENST00000409788.7
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  2. NM_001130850.2NP_001124322.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_001124322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AC084031, AF113536, AK000804, AK315692, DB455871
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    Q7Z4X0
    Related
    ENSP00000386642.3, ENST00000410084.7
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like
  3. NM_016289.4NP_057373.1  calcium-binding protein 39

    See identical proteins and their annotated locations for NP_057373.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents an alternate non-coding exon in the 5'UTR. The same protein is encoded by variants 1, 2, and 3.
    Source sequence(s)
    AF113536, AK000804, BC020570, BG773506, DA886579
    Consensus CDS
    CCDS2478.1
    UniProtKB/Swiss-Prot
    A8K8L7, Q9Y376
    UniProtKB/TrEMBL
    Q7Z4X0
    Related
    ENSP00000258418.5, ENST00000258418.10
    Conserved Domains (1) summary
    pfam08569
    Location:5334
    Mo25; Mo25-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    230712842..230821075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007076406.1 RNA Sequence

  2. XR_007076407.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    231195928..231304198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008486418.1 RNA Sequence

  2. XR_008486419.1 RNA Sequence