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ZNF44 zinc finger protein 44 [ Homo sapiens (human) ]

Gene ID: 51710, updated on 23-Nov-2021

Summary

Official Symbol
ZNF44provided by HGNC
Official Full Name
zinc finger protein 44provided by HGNC
Primary source
HGNC:HGNC:13110
See related
Ensembl:ENSG00000197857 MIM:194542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF; KOX7; ZNF55; ZNF58; GIOT-2; ZNF504
Expression
Ubiquitous expression in thyroid (RPKM 2.6), kidney (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF44 in Genome Data Viewer
Location:
19p13.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12224686..12294898, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12382623..12405698, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372275 Neighboring gene ZNF625-ZNF20 readthrough (NMD candidate) Neighboring gene zinc finger protein 625 Neighboring gene zinc finger protein 136 Neighboring gene uncharacterized LOC100289333 Neighboring gene ribosomal protein L28 pseudogene 5 Neighboring gene ribosomal protein S2 pseudogene 53 Neighboring gene zinc finger protein 563 Neighboring gene zinc finger protein 442 Neighboring gene ribosomal protein S29 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434F1811, DKFZp686L21136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 44
Names
gonadotropin inducible transcription repressor-2
gonadotropin-inducible ovary transcription repressor 2
zinc finger protein 55
zinc finger protein 58
zinc finger protein KOX7
zinc finger protein ZnFP12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164276.2NP_001157748.1  zinc finger protein 44 isoform 1

    See identical proteins and their annotated locations for NP_001157748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA525756, AK297528, BC001868, BE766488
    Consensus CDS
    CCDS54223.1
    UniProtKB/Swiss-Prot
    P15621
    Related
    ENSP00000348419.5, ENST00000356109.10
    Conserved Domains (5) summary
    smart00349
    Location:5288
    KRAB; krueppel associated box
    COG5048
    Location:244655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:582602
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5288
    KRAB; KRAB box
    pfam13465
    Location:595619
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001353549.2NP_001340478.1  zinc finger protein 44 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform 3.
    Source sequence(s)
    AC012618
    Conserved Domains (2) summary
    COG5048
    Location:164575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:502522
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001353550.2NP_001340479.1  zinc finger protein 44 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform 3.
    Source sequence(s)
    AC012618
    Conserved Domains (2) summary
    COG5048
    Location:164575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:502522
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001353551.1NP_001340480.1  zinc finger protein 44 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform 3.
    Source sequence(s)
    AC012618
    Conserved Domains (2) summary
    COG5048
    Location:164575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:502522
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001353552.2NP_001340481.1  zinc finger protein 44 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 4.
    Source sequence(s)
    AC012618
    Conserved Domains (2) summary
    COG5048
    Location:84495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422442
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001353553.2NP_001340482.1  zinc finger protein 44 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 4.
    Source sequence(s)
    AC012618
    Conserved Domains (2) summary
    COG5048
    Location:84495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422442
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_016264.4NP_057348.3  zinc finger protein 44 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the N-terminus, compared to isoform 1.
    Source sequence(s)
    AA525756, AC012618, BC001868, DA815414
    Consensus CDS
    CCDS45988.1
    UniProtKB/TrEMBL
    F8W7T7
    Related
    ENSP00000347910.5, ENST00000355684.6
    Conserved Domains (5) summary
    smart00349
    Location:440
    KRAB; krueppel associated box
    COG5048
    Location:196607
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:534554
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:440
    KRAB; KRAB box
    pfam13465
    Location:547571
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12224686..12294898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528062.3XP_011526364.1  zinc finger protein 44 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:4278
    KRAB; krueppel associated box
    COG5048
    Location:234645
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:572592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4278
    KRAB; KRAB box
    pfam13465
    Location:585609
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011528066.2XP_011526368.1  zinc finger protein 44 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:152563
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:503527
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_002958323.1 RNA Sequence

  2. XR_002958321.1 RNA Sequence

  3. XR_001753702.1 RNA Sequence

  4. XR_001753701.1 RNA Sequence

  5. XR_002958322.1 RNA Sequence

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