Format

Send to:

Choose Destination

HECA hdc homolog, cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 51696, updated on 21-Dec-2019

Summary

Official Symbol
HECAprovided by HGNC
Official Full Name
hdc homolog, cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:21041
See related
Ensembl:ENSG00000112406 MIM:607977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HDC; HDCL; HHDC; dJ225E12.1
Summary
This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 16.9), spleen (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See HECA in Genome Data Viewer
Location:
6q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (139135080..139180802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (139456249..139501946)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene epithelial cell transforming 2 like Neighboring gene RALBP1 associated Eps domain containing 1 Neighboring gene ABRA C-terminal like Neighboring gene Sharpr-MPRA regulatory region 4168 Neighboring gene taxilin beta Neighboring gene uncharacterized LOC102723690 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory tube development NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
headcase protein homolog
Names
headcase homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016217.3NP_057301.1  headcase protein homolog

    See identical proteins and their annotated locations for NP_057301.1

    Status: REVIEWED

    Source sequence(s)
    AB033492, AL031772, BC070068
    Consensus CDS
    CCDS5194.1
    UniProtKB/Swiss-Prot
    Q9UBI9
    Related
    ENSP00000356630.2, ENST00000367658.3
    Conserved Domains (2) summary
    pfam15353
    Location:93191
    HECA; Headcase protein family homologue
    pfam16002
    Location:343534
    Headcase; Headcase protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    139135080..139180802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center