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ASB2 ankyrin repeat and SOCS box containing 2 [ Homo sapiens (human) ]

Gene ID: 51676, updated on 9-Jul-2021

Summary

Official Symbol
ASB2provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 2provided by HGNC
Primary source
HGNC:HGNC:16012
See related
Ensembl:ENSG00000100628 MIM:605759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASB-2
Summary
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Biased expression in heart (RPKM 15.5), prostate (RPKM 8.6) and 12 other tissues See more
Orthologs
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Genomic context

See ASB2 in Genome Data Viewer
Location:
14q32.12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (93934160..93976739, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94400512..94442916, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370631 Neighboring gene FAM181A antisense RNA 1 Neighboring gene family with sequence similarity 181 member A Neighboring gene microRNA 4506 Neighboring gene uncharacterized LOC107984663 Neighboring gene coiled-coil domain containing 197

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40044

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart looping IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in podosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 2
Names
ankyrin repeat and SOCS box-containing protein 2a

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202429.2NP_001189358.1  ankyrin repeat and SOCS box protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001189358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB488462
    Consensus CDS
    CCDS55940.1
    UniProtKB/Swiss-Prot
    Q96Q27
    UniProtKB/TrEMBL
    A0A024R6E7
    Related
    ENSP00000451575.1, ENST00000555019.6
    Conserved Domains (4) summary
    cd00204
    Location:232357
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03721
    Location:591635
    SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
    pfam12796
    Location:308396
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:237268
    ANK; ANK repeat [structural motif]
  2. NM_016150.5NP_057234.2  ankyrin repeat and SOCS box protein 2 isoform 2

    See identical proteins and their annotated locations for NP_057234.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AJ251238, BC032354
    Consensus CDS
    CCDS9915.1
    UniProtKB/Swiss-Prot
    Q96Q27
    Related
    ENSP00000320675.4, ENST00000315988.8
    Conserved Domains (4) summary
    cd00204
    Location:184309
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03721
    Location:543587
    SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
    sd00045
    Location:189220
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:59109
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    93934160..93976739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267758.3XP_005267815.1  ankyrin repeat and SOCS box protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005267815.1

    UniProtKB/Swiss-Prot
    Q96Q27
    UniProtKB/TrEMBL
    A0A024R6E7
    Conserved Domains (4) summary
    cd00204
    Location:232357
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03721
    Location:591635
    SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
    pfam12796
    Location:308396
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:237268
    ANK; ANK repeat [structural motif]
  2. XM_017021369.2XP_016876858.1  ankyrin repeat and SOCS box protein 2 isoform X2

  3. XM_011536834.3XP_011535136.1  ankyrin repeat and SOCS box protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011535136.1

    Conserved Domains (4) summary
    cd00204
    Location:180305
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03721
    Location:539583
    SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
    pfam12796
    Location:256344
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:185216
    ANK; ANK repeat [structural motif]
  4. XM_011536835.3XP_011535137.1  ankyrin repeat and SOCS box protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011535137.1

    Related
    ENSP00000450940.1, ENST00000555507.5
    Conserved Domains (4) summary
    cd00204
    Location:130255
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:206294
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:135166
    ANK; ANK repeat [structural motif]
    cl02533
    Location:489533
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1048728..1091132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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