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SARAF store-operated calcium entry associated regulatory factor [ Homo sapiens (human) ]

Gene ID: 51669, updated on 13-Jan-2020

Summary

Official Symbol
SARAFprovided by HGNC
Official Full Name
store-operated calcium entry associated regulatory factorprovided by HGNC
Primary source
HGNC:HGNC:28789
See related
Ensembl:ENSG00000133872 MIM:614768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XTP3; FOAP-7; TMEM66; HSPC035
Expression
Ubiquitous expression in brain (RPKM 148.3), adrenal (RPKM 121.7) and 25 other tissues See more
Orthologs

Genomic context

See SARAF in Genome Data Viewer
Location:
8p12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30063003..30083208, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29920609..29940649, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 1218, pseudogene Neighboring gene leptin receptor overlapping transcript like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene membrane bound O-acyltransferase domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 66 (TMEM66) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8721, FLJ22274

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of store-operated calcium entry IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
store-operated calcium entry-associated regulatory factor
Names
HBV X-transactivated gene 3 protein
HBV XAg-transactivated protein 3
SARAF long isoform
SARAF short isoform
SOCE-associated regulatory factor
testicular secretory protein Li 59
transmembrane protein 66

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284239.1NP_001271168.1  store-operated calcium entry-associated regulatory factor isoform 2

    See identical proteins and their annotated locations for NP_001271168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC044849, AK315956, BM280420, DC359554
    Consensus CDS
    CCDS64866.1
    UniProtKB/Swiss-Prot
    Q96BY9
    Related
    ENSP00000441351.1, ENST00000545648.2
    Conserved Domains (1) summary
    pfam06682
    Location:2167
    SARAF; SOCE-associated regulatory factor of calcium homoeostasis
  2. NM_016127.6NP_057211.4  store-operated calcium entry-associated regulatory factor isoform 1 precursor

    See identical proteins and their annotated locations for NP_057211.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC044849
    Consensus CDS
    CCDS6074.1
    UniProtKB/Swiss-Prot
    Q96BY9
    UniProtKB/TrEMBL
    A0A140VK59
    Related
    ENSP00000256255.6, ENST00000256255.11
    Conserved Domains (1) summary
    pfam06682
    Location:24339
    SARAF; SOCE-associated regulatory factor of calcium homoeostasis

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30063003..30083208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013569.1XP_016869058.1  store-operated calcium entry-associated regulatory factor isoform X3

    UniProtKB/TrEMBL
    B7Z307
    Conserved Domains (1) summary
    pfam06682
    Location:2303
    SARAF; SOCE-associated regulatory factor of calcium homoeostasis
  2. XM_017013570.2XP_016869059.1  store-operated calcium entry-associated regulatory factor isoform X4

    Related
    ENSP00000427769.1, ENST00000518296.5
  3. XM_017013567.2XP_016869056.1  store-operated calcium entry-associated regulatory factor isoform X1

  4. XM_017013568.1XP_016869057.1  store-operated calcium entry-associated regulatory factor isoform X2

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