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HSPB11 heat shock protein family B (small) member 11 [ Homo sapiens (human) ]

Gene ID: 51668, updated on 17-Jun-2019

Summary

Official Symbol
HSPB11provided by HGNC
Official Full Name
heat shock protein family B (small) member 11provided by HGNC
Primary source
HGNC:HGNC:25019
See related
Ensembl:ENSG00000081870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP25; IFT25; C1orf41; HSPCO34
Expression
Ubiquitous expression in thyroid (RPKM 22.0), lymph node (RPKM 13.3) and 25 other tissues See more
Orthologs

Genomic context

See HSPB11 in Genome Data Viewer
Location:
1p32.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (53921561..53946308, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54387234..54411975, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Yip1 domain family member 1 Neighboring gene Sharpr-MPRA regulatory region 3939 Neighboring gene iodothyronine deiodinase 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene Sharpr-MPRA regulatory region 11594 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Intraflagellar transport, organism-specific biosystem (from REACTOME)
    Intraflagellar transport, organism-specific biosystemIntraflagellar transport (IFT) is a motor-based process that controls the anterograde and retrograde transport of large protein complexes, ciliary cargo and structural components along the ciliary ax...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
NOT cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
left/right axis specification IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary tip TAS
Traceable Author Statement
more info
 
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium TAS
Traceable Author Statement
more info
 
intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intraciliary transport particle B ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
intraflagellar transport protein 25 homolog
Names
heat shock protein beta-11
heat shock protein family B (small), member 11
intraflagellar transport 25 homolog
placental protein 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316935.1NP_001303864.1  intraflagellar transport protein 25 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC005245, HY179788
    Consensus CDS
    CCDS41341.1
    UniProtKB/Swiss-Prot
    Q9Y547
    Conserved Domains (1) summary
    pfam00754
    Location:19125
    F5_F8_type_C; F5/8 type C domain
  2. NM_016126.3NP_057210.2  intraflagellar transport protein 25 homolog

    See identical proteins and their annotated locations for NP_057210.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more abundant protein-coding transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC005245, DB480705
    Consensus CDS
    CCDS41341.1
    UniProtKB/Swiss-Prot
    Q9Y547
    Related
    ENSP00000194214.5, ENST00000194214.9
    Conserved Domains (1) summary
    pfam00754
    Location:19125
    F5_F8_type_C; F5/8 type C domain

RNA

  1. NR_133632.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AW024033, BC005245, BF967485
  2. NR_133633.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC005245, DA133366, DB480705

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    53921561..53946308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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